ArticleEmerging infectious diseases2019
Donor-Derived Genotype 4 Hepatitis E Virus Infection, Hong Kong, China, 2018.
Article in Emerging infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Treatment for chronic hepatitis E virus infection: A systematic review and meta-analysis.Journal of viral hepatitis · 2021Pooled it
- Hepatitis E virus and renal injury: A review of pathogenesis, pathology, and clinical management.Infectious medicine · 2026Review
- Donor-derived viral infections: the usual suspects and the new kids on the block.Transplant international : official journal of the European Society for Organ Transplantation · 2026Review
- Hepatitis E Virus in the Role of an Emerging Food-Borne Pathogen.Microorganisms · 2025Review
- Optimization of immunosuppression strategies for the establishment of chronic hepatitis E virus infection in rabbits.Journal of virology · 2024Article
- The question of screening organ donors for hepatitis e virus: a case report of transmission by kidney transplantation in France and a review of the literature.Virology journal · 2024Review
- Redeveloping antigen detection kits for the diagnosis of rat hepatitis E virus.Journal of clinical microbiology · 2023Article
- Animal Models for Hepatitis E Virus.Advances in experimental medicine and biology · 2023Article
- Puzzles for Hepatitis E Virus.Advances in experimental medicine and biology · 2023Article
- A small animal model of chronic hepatitis E infection using immunocompromised rats.JHEP reports : innovation in hepatology · 2022Article
- [Consensus on prevention and treatment of hepatitis E].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2022Article
- Article
- Risk assessment of hepatitis E transmission through tissue allografts.World journal of gastrointestinal pathophysiology · 2022Review
- Advances in Hepatitis E Virus Biology and Pathogenesis.Viruses · 2021Review
- Seroprevalence of Hepatitis E Virus in Moose (Viruses · 2021Article
- Risk of Hepatitis E among Persons Who Inject Drugs in Hong Kong: A Qualitative and Quantitative Serological Analysis.Microorganisms · 2020Article
- Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure.Journal of immunology research · 2020Article
- Prevalence of anti-hepatitis E virus antibodies in domestic animal from three representative provinces of Burkina Faso.Veterinary and animal science · 2019Article
- Genetic Variability and Evolution of Hepatitis E Virus.Viruses · 2019Review
- Identifying Circular RNAs in HepG2 Expressing Genotype IV Swine Hepatitis E Virus ORF3 Via Whole Genome Sequencing.Cell transplantationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hepatitis E virus (HEV) genotype 4 (HEV-4) is an emerging cause of acute hepatitis in China. Less is known about the clinical characteristics and natural history of HEV-4 than HEV genotype 3 infections in immunocompromised patients. We report transmission of HEV-4 from a deceased organ donor to 5 transplant recipients. The donor had been viremic but HEV IgM and IgG seronegative, and liver function test results were within reference ranges. After a mean of 52 days after transplantation, hepatitis developed in all 5 recipients; in the liver graft recipient, disease was severe and with progressive portal hypertension. Despite reduced immunosuppression, all HEV-4 infections progressed to persistent hepatitis. Four patients received ribavirin and showed evidence of response after 2 months. This study highlights the role of organ donation in HEV transmission, provides additional data on the natural history of HEV-4 infection, and points out differences between genotype 3 and 4 infections in immunocompromised patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.