Evidence map›Paper›PMID 30788683›Full record

ArticleDigestive diseases and sciences2019

Distinct Expression Patterns of Two Tumor Necrosis Factor Superfamily Member 15 Gene Isoforms in Human Colon Cancer.

Tomasz Jerzy Ślebioda, Marcin Stanisławowski, Marta Cyman, Piotr Mieczysław Wierzbicki, Dorota Żurawa-Janicka, Jarek Kobiela, Wojciech Makarewicz, Marek Guzek, Zbigniew Kmieć

Open access · hybridAbstract read
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In one paragraph

Article in Digestive diseases and sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Genomic strategies for drug repurposing.Journal of the Egyptian National Cancer Institute · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Tomasz Jerzy ŚlebiodaDepartment of Histology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland. t.slebioda@gumed.edu.pl.ORCID http://orcid.org/0000-0002-0591-5248
Marcin StanisławowskiDepartment of Histology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland.
Marta CymanDepartment of Histology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland.
Piotr Mieczysław WierzbickiDepartment of Histology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland.
Dorota Żurawa-JanickaDepartment of Medical and General Biochemistry, University of Gdańsk, Wita Stwosza 59, 80-308, Gdańsk, Poland.
Jarek KobielaDepartment of General, Endocrine and Transplant Surgery, Medical University of Gdańsk, Mariana Smoluchowskiego 17, 80-001, Gdańsk, Poland.
Wojciech MakarewiczDepartment of Oncological Surgery, Medical University of Gdańsk, Mariana Smoluchowskiego 17, 80-001, Gdańsk, Poland.
Marek GuzekDepartment of Gastroenterology and Hepatology, Medical University of Gdańsk, Mariana Smoluchowskiego 17, 80-001, Gdańsk, Poland.
Zbigniew KmiećDepartment of Histology, Medical University of Gdańsk, Dębinki 1, 80-211, Gdańsk, Poland.
Gdańsk Medical University · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTumor necrosis factor superfamily member 15 (TNFSF15) gene is involved in development of several cancers. It encodes two proteins: tumor necrosis factor ligand-related molecule 1A (TL1A) and vascular endothelial growth inhibitor 192 (VEGI-192). The main receptor for TL1A is death receptor 3 (DR3).

aimsWe investigated expression of TL1A, VEGI-192, and DR3 transcripts in different stages of colon cancer and compared them with survival of patients. We also aimed to reveal possible effects of microsatellite instability (MSI) and selected TNFSF15 single-nucleotide polymorphisms (SNPs) on expression of this gene.

methodsForty-five healthy individuals and 95 colon cancer patients were included in the study. Expression of VEGI-192, TL1A, and DR3 was measured by quantitative PCR. SNP and MSI analyses were performed on DNA isolated from normal or cancer tissue.

resultsExpression of VEGI-192 and TL1A was elevated in colon cancer, although the level of VEGI-192 decreased, while the level of TL1A increased with the progression of cancer. Patients with low expression of TL1A and/or high expression of VEGI-192 in tumor-transformed tissue showed longer survival. DR3 expression was decreased in the cancer, but it did not change with the tumor progression. Alleles T of rs6478108 and G of rs6478109 SNPs were associated with elevated expression of the TNFSF15 gene. There was no relation between the MSI status and TNFSF15 expression levels.

conclusionsExpression of the TNFSF15 gene isoforms was associated with the progression of colon cancer. Levels of TL1A and VEGI-192 transcripts can be considered as independent prognostic factors for colon cancer.

Indexed as

Polymorphism, Single NucleotideAgedBiomarkers, TumorCase-Control StudiesColonic NeoplasmsDisease ProgressionFemaleGene Expression Regulation, NeoplasticGenetic Predisposition to DiseaseHumansMaleMicrosatellite InstabilityMiddle AgedPhenotypeRNA, MessengerTumor Necrosis Factor Ligand Superfamily Member 15Biomarkers, TumorRNA, MessengerTNFSF15 protein, humanTumor Necrosis Factor Ligand Superfamily Member 15Advanced gastric cancerColon cancerTL1ATNFSF15VEGI-192

Identifiers

PMID30788683
PMCPMC6584785
OpenAlexW2917663551

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.