Evidence map›Paper›PMID 30788613›Full record

ReviewCurrent treatment options in neurology2019

The Comprehensive Management of Cerebellar Ataxia in Adults.

Christopher D Stephen, Kate T Brizzi, Marc A Bouffard, Pablo Gomery, Stacey L Sullivan, Julie Mello, Julie MacLean, Jeremy D Schmahmann

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current treatment options in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Contrastive Learning Model for Wearable-Based Ataxia Assessment.IEEE transactions on bio-medical engineering · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. In Search of Molecular Markers for Cerebellar Neurons.International journal of molecular sciences · 2021
    Review
  10. Palliative Care in Movement Disorders: an Evolving Field.Current neurology and neuroscience reports · 2021
    Review
  11. Update on the Treatment of Ataxia: Medication and Emerging Therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2020
    Review
  12. Review
  13. Article
  14. The Rise of Cerebellar Ataxia in South Korea: 2002-2016.Journal of clinical neurology (Seoul, Korea) · 2020
    Article
  15. Changes in standing stability with balance-based torso-weighting with cerebellar ataxia: A pilot study.Physiotherapy research international : the journal for researchers and clinicians in physical therapy · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Christopher D StephenAtaxia Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA. cstephen@mgh.harvard.edu.
Kate T BrizziAtaxia Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Marc A BouffardAtaxia Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Pablo GomeryDepartment of Urology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Stacey L SullivanSpeech Language Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Julie MelloPhysical Therapy, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Julie MacLeanOccupational Therapy, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Jeremy D SchmahmannAtaxia Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.
Harvard University · USMassachusetts General Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewIn this review, we present the multidisciplinary approach to the management of the many neurological, medical, social, and emotional issues facing patients with cerebellar ataxia. RECENT

findingsOur holistic approach to treatment, developed over the past 25 years in the Massachusetts General Hospital Ataxia Unit, is centered on the compassionate care of the patient and their family, empowering them through engagement, and including the families as partners in the healing process. We present the management of ataxia in adults, beginning with establishing an accurate diagnosis, followed by treatment of the multiple symptoms seen in cerebellar disorders, with a view to maximizing quality of life and effectively living with the consequences of ataxia. We discuss the importance of a multidisciplinary approach to the management of ataxia, including medical and non-medical management and the evidence base that supports these interventions. We address the pharmacological treatment of ataxia, tremor, and other associated movement disorders; ophthalmological symptoms; bowel, bladder, and sexual symptoms; orthostatic hypotension; psychiatric and cognitive symptoms; neuromodulation, including deep brain stimulation; rehabilitation including physical therapy, occupational therapy and speech and language pathology and, as necessary, involving urology, psychiatry, and pain medicine. We discuss the role of palliative care in late-stage disease. The management of adults with ataxia is complex and a team-based approach is essential.

Indexed as

Cerebellar ataxiaPalliative carePharmacological and non-pharmacological managementTreatment

Identifiers

PMID30788613
OpenAlexW2916955996

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.