ReviewCurrent neurology and neuroscience reports2019
Should We Care About Early Post-Stroke Rehabilitation? Not Yet, but Soon.
Review in Current neurology and neuroscience reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04688970 (Personalized Neurorehabilitative Precision Medicine - From Data to Therapies), which is not on this map. Cited by 29 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Personalized Neurorehabilitative Precision Medicine - From Data to Therapies
Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Poststroke eHealth Technologies-Based Rehabilitation for Upper Limb Recovery: Systematic Review.Journal of medical Internet research · 2025Pooled it
- What factors at discharge predict physical activity and walking outcomes 6 months after stroke? A systematic review.Clinical rehabilitation · 2024Pooled it
- Cycling using functional electrical stimulation therapy to improve motor function and activity in post-stroke individuals in early subacute phase: a systematic review with meta-analysis.Biomedical engineering online · 2024Pooled it
- Feasibility and outcomes of supplemental gait training by robotic and conventional means in acute stroke rehabilitation.Journal of neuroengineering and rehabilitation · 2023Trial
- Critical Period After Stroke Study (CPASS): A phase II clinical trial testing an optimal time for motor recovery after stroke in humans.Proceedings of the National Academy of Sciences of the United States of America · 2021Trial
- Post-stroke brain functional reorganization is associated with glymphatic dysfunction during stroke recovery.Brain informatics · 2025Article
- Changes of health-related quality of life within 6 months after stroke by clinical and sociodemographic factors.Scientific reports · 2025Article
- Impact of frailty on rehabilitation exercise adherence in patients with ischemic stroke.Frontiers in medicine · 2025Article
- The Association Between Ischemic Stroke Patients' Illness Perception and Adherence to Rehabilitation Exercises: An Analysis of a Moderated Chain Mediation Model.Patient preference and adherence · 2025Article
- The Role of Mirror Therapy in the Rehabilitation of the Upper Limb's Motor Deficits After Stroke: Narrative Review.Journal of clinical medicine · 2024Review
- Article
- Exoskeleton-assisted training to enhance lower limb motor recovery in subacute stroke: does timing matter? A pilot randomized trial.Frontiers in stroke · 2024Article
- Effect of intermittent theta burst stimulation on upper limb function in stroke patients: a systematic review and meta-analysis.Frontiers in neurology · 2024Article
- Developmental trajectory of care dependency in older stroke patients.Frontiers in neurology · 2024Article
- Hand rehabilitation based on the RobHand exoskeleton in stroke patients: A case series study.Frontiers in robotics and AI · 2023Article
- Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year involving 60 patients.Neural regeneration research · 2022Article
- Observational
- Development and feasibility testing of action observation training videos in acute stroke survivors: Preliminary findings.F1000Research · 2022Article
- Let the force guide you: a performance-based adaptive algorithm for postural training using haptic feedback.Frontiers in human neuroscience · 2022Article
- Clinical Evaluation of Different Treatment Strategies for Motor Recovery in Poststroke Rehabilitation during the First 90 Days.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewStudies in humans and animal models show that most recovery from impairment occurs in the first 1-3 months after stroke as a result of both spontaneous recovery as well as increased responsiveness to enriched environments and training. Improvement from impairment is attributable to a short-lived "sensitive period" of post-stroke plasticity defined by unique genetic, physiological, and structural events. Unfortunately, rehabilitative interventions in humans have not been able to exploit this sensitive period similar to that seen in animal models. Here, we review these data and suggest a path forward. RECENT
findingsPre-clinical data reveal underlying mechanisms that define the post-stroke sensitive period. These data are then discussed in the context of the spontaneous post-stroke recovery described in humans. Future work will need to capitalize on unique interactions between the sensitive period, spontaneous recovery, and novel types of rehabilitative interventions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.