Evidence map›Paper›PMID 30788464›Full record

ArticleSC ... conference proceedings. SC (Conference : Supercomputing)2015

Big Omics Data Experience.

Patricia Kovatch, Anthony Costa, Zachary Giles, Eugene Fluder, Hyung Min Cho, Svetlana Mazurkova

Abstract read
In one paragraph

Article in SC ... conference proceedings. SC (Conference : Supercomputing), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Optimizing High-Performance Computing Systems for Biomedical Workloads.IEEE International Symposium on Parallel & Distributed Processing, Workshops and Phd Forum : [proceedings]. IEEE International Symposium on Parallel & Distributed Processing, Workshops and Phd Forum · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Patricia KovatchIcahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, 212-241-6500.
Anthony CostaIcahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, 212-241-6500.
Zachary GilesIcahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, 212-241-6500.
Eugene FluderIcahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, 212-241-6500.
Hyung Min ChoIcahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, 212-241-6500.
Svetlana MazurkovaIcahn School of Medicine at Mount Sinai, 1 Gustave L. Levy Place, New York, NY 10029, 212-241-6500.

Funding

Transforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9M
NIH HHS S10 OD018522
6 · The paper itself

Abstract

As personalized medicine becomes more integrated into healthcare, the rate at which human genomes are being sequenced is rising quickly together with a concomitant acceleration in compute and storage requirements. To achieve the most effective solution for genomic workloads without re-architecting the industry-standard software, we performed a rigorous analysis of usage statistics, benchmarks and available technologies to design a system for maximum throughput. We share our experiences designing a system optimized for the "Genome Analysis ToolKit (GATK) Best Practices" whole genome DNA and RNA pipeline based on an evaluation of compute, workload and I/O characteristics. The characteristics of genomic-based workloads are vastly different from those of traditional HPC workloads, requiring different configurations of the scheduler and the I/O subsystem to achieve reliability, performance and scalability. By understanding how our researchers and clinicians work, we were able to employ techniques not only to speed up their workflow yielding improved and repeatable performance, but also to make more efficient use of storage and compute resources.

Indexed as

benchmarkingdesigngenomic sequencingGPFSHigh performancehigh throughput and data-intensive computingLSF and flash memorymanagementMeasurementparallel file systemsperformanceperformance analysisreliabilityscheduling and resource management

Identifiers

PMID30788464
PMCPMC6379072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.