ArticleJournal of the Endocrine Society2019
Successful Multimodal Treatment of an IGF2-Producing Solitary Fibrous Tumor With Acromegaloid Changes and Hypoglycemia.
Article in Journal of the Endocrine Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- A systematic review of literature on Insulin-like growth factor-2-mediated hypoglycaemia in non-islet cell tumours.Endocrinology, diabetes & metabolism · 2024Pooled it
- Pelvic Retroperitoneal Solitary Fibrous Tumor: Two Cases Including Doege-Potter Syndrome.Cureus · 2026Article
- Hypoglycaemia in a patient with undiagnosed Doege-Potter syndrome: A case report and narrative literature review.European journal of anaesthesiology and intensive care · 2026Review
- Acromegalic features and hypoglycemia: Doege-Potter syndrome.Caspian journal of internal medicine · 2026Article
- Solitary fibrous tumor: an updated review.Journal of pathology and translational medicine · 2026Article
- NICTH with secondary acromegaloid changes and severe hypoglycemia due to potentially insulin-like growth factor-2 mediated effects.Journal of diabetes and metabolic disorders · 2025Article
- [Hypoglycemia in a patient with pleural solitary fibrous tumor and response to pasireotide]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2025Article
- Radiation therapy alleviates Doege-Potter syndrome accompanied with severe aortic valve insufficiency: a case report and literature review.Frontiers in oncology · 2025Article
- Systemic metastasis in malignant solitary fibrous tumor of the liver: two case reports and literature review.Frontiers in oncology · 2024Article
- Review
- Histopathological features of giant mediastinal tumors-a literature review.Mediastinum (Hong Kong, China) · 2023Review
- Doege-Potter Syndrome; A Case of Solitary Fibrous Pleura Tumor Associated with Severe Hypoglycemia: A Case Report in Internal Medicine.Endocrine, metabolic & immune disorders drug targets · 2023Article
- Malignant fibroma presenting as a hypoglycemia and coma in a 45-year-old male patient: A case report.Clinical case reports · 2022Article
- Targeting-intratumoral-lactic-acidosis transcatheter-arterial-chemoembolization for non-islet cell tumor hypoglycemia secondary to a liver metastatic solitary fibrous tumor: A case report and literature review.Frontiers in endocrinology · 2022Review
- Non-islet cell tumor hypoglycemia concurrent with acromegalic features: A case report and literature review.Frontiers in surgery · 2022Article
- Successful multidisciplinary treatment of Doege-Potter syndrome: hypoglycaemia caused by paraneoplastic IGF-2 production by a metastatic haemangiopericytoma.BMJ case reports · 2021Article
- Doege-Potter syndrome by malignant solitary fibrous tumor of the liver: A case report and review of literature.World journal of gastrointestinal surgery · 2019Article
- Metastasis of a Solitary Fibrous Tumor in the Mandible: A Case Report.Cancer diagnosis & prognosisArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Doege-Potter syndrome with acromegaloid facial changes is extremely rare. Uncooked cornstarch along with glucocorticoids have been used as supportive care in patients with non-islet cell tumor hypoglycemia (NICTH). Preoperative embolization of hepatic solitary fibrous tumors (SFT) with NICTH has yielded unsatisfactory results. Herein we present the case of a 61-year-old man with a 3-month history of severe frequent hypoglycemic episodes and acromegaloid facial changes. During a spontaneous hypoglycemia (26 mg/dL), laboratory values showed a hypoinsulinemic pattern with low levels of GH, IGFPB3, and an IGF2/IGF1 ratio of 8.5:1. Cross-sectional imaging revealed a large (16 × 13 × 11 cm) hepatic tumor, and cytology was consistent with SFT. A preoperative right portal embolization was performed in an effort to induce normal remnant liver hypertrophy to allow for safe tumor resection. After the procedure, uncooked starch treatment followed by prednisone was started, achieving complete remission of hypoglycemic episodes in the preoperative setting. He subsequently underwent partial hepatectomy. The histologic diagnosis was compatible with a potentially malignant SFT. The patient had an excellent outcome with complete remission of hypoglycemia, improvement of facial acromegaloid changes, and no further evidence of disease. To our knowledge, this is the first case of a patient with Doege-Potter syndrome with acromegaloid facial changes induced by a potentially malignant liver SFT, treated successfully with a multimodal approach consisting of uncooked cornstarch, low-dose prednisone, preoperative embolization, and complete surgical resection. The use of cornstarch and low-dose glucocorticoids may be an adequate treatment in advance of undergoing surgery.
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