ArticleScience advances2019
Strictures of a microchannel impose fierce competition to select for highly motile sperm.
Article in Science advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 80 citations in OpenAlex.
- Sperm hyperactivation drives a circling-and-wandering swimming behavior.Nature communications · 2026Article
- Microfluidic automation improves oocyte recovery from follicular fluid of patients undergoing in vitro fertilization.Nature medicine · 2026Article
- Light-Dependent Switching of Circling Handedness in Microswimmer Navigation.Physical review letters · 2026Article
- Simple and rapid microfluidic device for processing raw human semen and separation of motile sperm based on their intrinsic behavior and morphology.Scientific reports · 2025Article
- Tunable motile sperm separation based on sperm persistence in migrating through shear barriers.Biomicrofluidics · 2024Article
- Article
- Reproductive Tract Mucus May Influence the Sex of Offspring in Cattle: Study in Cows That Have Repeatedly Calved Single-Sex Offspring.Veterinary sciences · 2024Article
- Microfluidics-A novel technique for high-quality sperm selection for greater ART outcomes.FASEB bioAdvances · 2024Review
- The surprising complexity and diversity of sperm storage structures across Galliformes.Ecology and evolution · 2024Article
- Qualified sperm selection based on the rheotaxis and thigmotaxis in a microfluidic system.Biomedical engineering letters · 2023Article
- Design of a gradient-rheotaxis microfluidic chip for sorting of high-quality Sperm with progressive motility.iScience · 2023Article
- A novel microfluidic device with parallel channels for sperm separation using spermatozoa intrinsic behaviors.Scientific reports · 2023Article
- Lab-on-chip (LoC) application for quality sperm selection: An undelivered promise?Open research Europe · 2023Review
- Review
- Mammalian sperm hyperactivation regulates navigation via physical boundaries and promotes pseudo-chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Viscous Cervical Environment-on-a-Chip for Selecting High-Quality Sperm from Human Semen.Biomedicines · 2021Article
- Rolling controls sperm navigation in response to the dynamic rheological properties of the environment.eLife · 2021Article
- Advances in sperm analysis: techniques, discoveries and applications.Nature reviews. Urology · 2021Review
- Curvature in the reproductive tract alters sperm-surface interactions.Nature communications · 2021Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Investigating sperm locomotion in the presence of external fluid flow and geometries simulating the female reproductive tract can lead to a better understanding of sperm motion during fertilization. Using a microfluidic device featuring a stricture that simulates the fluid mechanical properties of narrow junctions inside the female reproductive tract, we documented the gate-like role played by the stricture in preventing sperm with motilities below a certain threshold from advancing through the stricture to the other side (i.e., fertilization site). All the slower sperm accumulate below (i.e., in front of) the stricture and swim in a butterfly-shaped path between the channel walls, thus maintaining the potential for penetrating the stricture and ultimately advancing toward the fertilization site. Accumulation below the stricture occurs in a hierarchical manner so that dense concentrations of sperm with higher velocities remain closer to the stricture, with more sparsely distributed arrays of lower-velocity sperm lagging behind.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.