Evidence map›Paper›PMID 30788383›Full record

ArticleMolecular therapy. Methods & clinical development2019

Human Galectin-1 Improves Sarcolemma Stability and Muscle Vascularization in the mdx Mouse Model of Duchenne Muscular Dystrophy.

Ryan D Wuebbles, Vivian Cruz, Pam Van Ry, Pamela Barraza-Flores, Paul D Brewer, Peter Jones, Dean J Burkin

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ryan D WuebblesDepartment of Pharmacology, Center for Molecular Medicine, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
Vivian CruzStrykaGen Corporation, Reno, NV 89557, USA.
Pam Van RyDepartment of Pharmacology, Center for Molecular Medicine, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
Pamela Barraza-FloresDepartment of Pharmacology, Center for Molecular Medicine, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
Paul D BrewerStrykaGen Corporation, Reno, NV 89557, USA.
Peter JonesDepartment of Pharmacology, Center for Molecular Medicine, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
Dean J BurkinDepartment of Pharmacology, Center for Molecular Medicine, University of Nevada, Reno School of Medicine, Reno, NV 89557, USA.
University of Nevada, Reno · US

Funding

Outreach/Diversity/Pipeline ProjectP20GM103440 · NIGMS · UNIVERSITY OF NEVADA RENO · PI Eduardo A Robleto · 2012 to 2026
$58.0M
Laminin protein therapy for Congenital Muscular DystrophyR01AR064338 · NIAMS · UNIVERSITY OF NEVADA RENO · PI BURKIN, DEAN J. · 2014 to 2018
$1.6M
Galectin 1: A novel small protein therapy for Duchenne muscular dystrophyR41AR067014 · NIAMS · STRYKAGEN CORPORATION · PI BURKIN, DEAN J. · 2014 to 2015
$225k
Galectin-1 Protein Therapy for Congenital Muscular DystrophyR41AR073696 · NIAMS · STRYKAGEN CORPORATION · PI BURKIN, DEAN J. · 2018 to 2018
$225k
NIAMS NIH HHS R01 AR064338NIAMS NIH HHS R41 AR067014NIAMS NIH HHS R41 AR073696NIGMS NIH HHS P20 GM103440
6 · The paper itself

Abstract

Duchenne muscular dystrophy (DMD) is a devastating disease caused by mutations in the dystrophin gene that result in the complete absence of dystrophin protein. We have shown previously that recombinant mouse Galectin-1 treatment improves physiological and histological outcome measures in the

Indexed as

biologicDuchenne muscular dystrophyGalectin-1protein therapeuticvascularization

Identifiers

PMID30788383
PMCPMC6369265
OpenAlexW2911650224

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.