ArticleIranian journal of public health2018
The Expression of SOCS and NF-ϰB p65 in Hypopharyngeal Carcinoma.
Article in Iranian journal of public health, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors at 3 institutions in 1 country.
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Abstract
backgroundHypopharyngeal carcinoma is one of the most common types of head and neck tumors. Suppressers of cytokine signalling (SOCS) family members are key regulators of cytokine homeostasis, they play important roles in the process of cell proliferation, differentiation, maturation and apoptosis, and participate in the occurrence and development of tumor. The abnormal activation of NF-ϰB is an important feature of the tumor. The aim of this study was to investigate the relationships among SOCS, NF-ϰB p65 and hypopharyngeal carcinoma development.C.
methodsWe included 72 hypopharyngeal cancer patients and 9 swallow cyst patients. The patients were recruited at The Second Hospital of Shandong University (Jinan, China) between 2014 and 2016. The mRNA and protein expression levels of SOCS-1, SOCS-3 and NF-ϰB p65 in hypopharyngeal carcinoma tissues, para-cancerous tissues and control tissues were detected by RT-PCR and Western blot analysis, respectively.
resultsHypopharyngeal carcinoma tissues had lower level expression of SOCS-1 and SOCS-3 than pericarcinoma tissues, but there was no significant difference, while cancer tissues had significantly higher level expression of NF-ϰB p65 than that of pericarcinoma tissues (0.412±0.266, 0.281±0.231, t=2.969,
conclusionSOCS-1, SOCS-3 may be protective factors while NF-ϰB p65 could be a harmful factor in hypopharyngeal carcinoma.
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30788302PMC6379622W2911802525What OpenQuestion holds
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