ReviewWorld journal of orthopedics2019
Allergy in total knee replacement surgery: Is it a real problem?
Review in World journal of orthopedics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- "Systematic review and meta-analysis of ceramic coated implants in total knee arthroplasty. Comparable mid-term results to uncoated implants."Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- FEA Simulation of Crimping Pressure Distribution in Titanium and Teflon Stapedotomy Prostheses.Materials (Basel, Switzerland) · 2025Article
- Clinic and Ultrasound Evaluation of Suction Drainage in Total Knee Arthroplasty Procedure: A Multicentric Prospective Trial.Indian journal of orthopaedics · 2025Article
- Mid-Term Results of a Cemented Titanium-Niobium Nitride-Coated Mobile Knee in Primary Total Knee Arthroplasty.Journal of clinical medicine · 2025Article
- The effect of allergies on outcomes following shoulder arthroplasty: A national database analysis of 154,478 patients.Shoulder & elbow · 2024Article
- First Italian Experience with the Oxinium Metal-Backed Fixed-Bearing Medial Journey II Unicompartmental Knee System: Promising Short-Term Outcomes of 145 Cases.Journal of clinical medicine · 2024Article
- Similar clinical and radiographic outcomes after two different hypoallergenic medial unicompartmental knee in patients with metal allergy.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2023Article
- Neuropathy Dermatitis: An Underdocumented Complication Following Total Knee Arthroplasty.Indian journal of orthopaedics · 2023Article
- Hypoallergenic unicompartmental knee arthroplasty and return to sport: comparison between Oxidized Zirconium and Titanium Niobium Nitride.Acta bio-medica : Atenei Parmensis · 2022Article
- Evaluation of local tissue peri-implant reaction in total knee arthroplasty failure cases.Therapeutic advances in musculoskeletal disease · 2022Article
- The influence of HLA genotype on the development of metal hypersensitivity following joint replacement.Communications medicine · 2022Article
- No Clinical or Radiographic Differences Between Cemented Cobalt-Chromium and Titanium-Niobium Nitride Mobile-Bearing Unicompartmental Knee Arthroplasty.Indian journal of orthopaedics · 2021Article
- Self-reported metal hypersensitivity in patients undergoing unicondylar knee arthroplasty.Journal of clinical orthopaedics and trauma · 2021Article
- SKINTED: A Rare Complication After Total Knee Arthroplasty.Arthroplasty today · 2020Article
- Early Outcomes of an Alternative Bearing Surface in Primary Total Knee Arthroplasty in Patients with Self-reported Metal Allergy.Arthroplasty today · 2020Article
- Hip and knee replacement in patients with ochronosis: Clinical experience and literature review.Orthopedic reviews · 2020Article
- Efficacy of postoperative drainage in total knee arthroplasty: Review of the literature.Orthopedic reviews · 2020Article
- What are the benefits of robotic-assisted total knee arthroplasty over conventional manual total knee arthroplasty? A systematic review of comparative studies.Orthopedic reviews · 2020Article
- Identification of pigments related to allergic tattoo reactions in 104 human skin biopsies.Contact dermatitis · 2020Article
- Effect of thermomechanical treatment on the mechanical and microstructural evolution of a β-type Ti-40.7Zr-24.8Nb alloy.Bioactive materials · 2019Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Total knee arthroplasty is a common procedure, with extremely good clinical results. Despite this success, it produces 20% unsatisfactory results. Among the causes of these failures is metal hypersensitivity. Metal sensitization is higher in patients with a knee arthroplasty than in the general population and is even higher in patients undergoing revision surgery. However, a clear correlation between metal sensitization and symptomatic knee after surgery has not been ascertained. Surely, patients with a clear history of metal allergy must be carefully examined through dermatological and laboratory testing before surgery. There is no globally accepted diagnostic algorithm or laboratory test to diagnose metal hypersensitivity or metal reactions. The patch test is the most common test to determine metal hypersensitivity, though presenting some limitations. Several laboratory assays have been developed, with a higher sensitivity compared to patch testing, yet their clinical availability is not widespread, due to high costs and technical complexity. Symptoms of a reaction to metal implants present across a wide spectrum, ranging from pain and cutaneous dermatitis to aseptic loosening of the arthroplasty. However, although cutaneous and systemic hypersensitivity reactions to metals have arisen, thereby increasing concern after joint arthroplasties, allergies against implant materials remain quite rare and not a well-known problem. The aim of the following paper is to provide an overview on diagnosis and management of metal hypersensitivity in patients who undergo a total knee arthroplasty in order clarify its real importance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.