Evidence map›Paper›PMID 30788214›Full record

ArticleEpilepsy & behavior case reports2019

Forced normalization after turning off vagus nerve stimulation in Lennox-Gastaut syndrome.

Sydney Lee, Alyssa Denton, Lady Diana Ladino, Karen Waterhouse, Aleksander Vitali, Jose Francisco Tellez-Zenteno

Open access · goldAbstract readCase Reports
In one paragraph

Article in Epilepsy & behavior case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Article
  3. Externalization of an infected vagus nerve stimulator generator without a break in anti-seizure therapy: a technical note.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Sydney LeeCollege of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Alyssa DentonCollege of Medicine, University of Saskatchewan, Saskatoon, SK, Canada.
Lady Diana LadinoEpilepsy Program, Hospital Pablo Tobón Uribe-University of Antioquia, Neuroclinica, Medellín, Colombia.
Karen WaterhouseDivision of Neurology, Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
Aleksander VitaliDivision of Neurosurgery, Department of Medicine, University of Saskatchewan, Canada.
Jose Francisco Tellez-ZentenoDivision of Neurology, Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
University of Saskatchewan · CAUniversidad de Antioquia · CO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Forced normalization is the development of psychiatric symptoms in a patient experiencing remission of seizures. We present a case of Lennox Gastaut syndrome in which forced normalization developed after vagus nerve stimulation was stopped. The patient had drug resistant epilepsy and failed anti-seizure drugs, vagus nerve stimulation, and a partial callosotomy. The patient had multiple types of seizures including drop attacks, absences, and tonic-clonic seizures. He tried vagus nerve stimulation for two years without success. Forced normalization developed after the vagus nerve stimulator was turned off. This is the first case to our knowledge to describe forced normalization after turning off the vagus nerve stimulator.

Indexed as

ACTH, adrenocorticotropic hormoneASD, anti-seizure drugEEG, electroencephalographyFN, forced normalizationForced normalizationLennox Gastaut syndromeLGS, Lennox Gastaut syndromeVagus nerve stimulationVNS, vagus nerve stimulation

Identifiers

PMID30788214
PMCPMC6369242
OpenAlexW2914076346

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.