ArticleJournal of gastrointestinal oncology2019
Lower lymph node yield following neoadjuvant therapy for rectal cancer has no clinical significance.
Article in Journal of gastrointestinal oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Understanding Textbook outcome failure after robotic colorectal cancer surgery: a multicenter domain-specific analysis.Journal of robotic surgery · 2026Observational
- Volume-Outcome Relationships in Total Mesorectal Excision Quality and Grading: A National Cancer Database Study.Annals of surgical oncology · 2026Article
- Significance of nodal yield after rectal resection in the TNT era: does count matter?BMC cancer · 2026Article
- Tailored minimum examined lymph node threshold for colon cancer from large multi database analysis.Scientific reports · 2026Article
- Lymph Nodal Yield and Pattern of Spread in Carcinoma Rectum: A Study on Non-formalin Fixed Freshly Resected Surgical Specimen Dissection.Indian journal of surgical oncology · 2025Article
- Short-term outcomes of short- and long-course chemoradiotherapy before total mesorectal excision for locally advanced rectal tumors: A single-center study in Taiwan utilizing propensity score matching.Journal of the Chinese Medical Association : JCMA · 2024Article
- Prognostic significance of lymph node yield on oncologic outcomes according to tumor response after preoperative chemoradiotherapy in rectal cancer patients.Annals of coloproctology · 2023Article
- Optimal Lymph Node Yield for Survival Prediction in Rectal Cancer Patients After Neoadjuvant Therapy.Cancer management and research · 2021Article
- Lymph Node Ratio as a Prognostic Marker in Rectal Cancer Survival: A Systematic Review and Meta-Analysis.Cureus · 2020Article
- A lower cut-off for lymph node harvest predicts for poorer overall survival after rectal surgery post neoadjuvant chemoradiotherapy.World journal of surgical oncology · 2020Article
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2 authors.
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Abstract
backgroundObtaining 12 lymph nodes following resection for rectal cancer is an important prognostic marker. However, patients who have received neoadjuvant therapy are known to have a lower lymph node yield. We conducted this study to determine the clinical significance of evaluating <12 versus ≥12 lymph nodes in individuals who underwent surgery following neoadjuvant therapy for rectal cancer.
methodsA retrospective analysis of all patients who received neoadjuvant therapy for locally advanced rectal cancer between January 2008 and December 2014 followed by proctectomy was conducted.
resultsIn total, 217 patients were treated for rectal cancer. Mean follow-up was 23.4 (interquartile range, 9-40.5) months. Sixty-three (29.0%) patients received neoadjuvant therapy. There was a statistically significant difference in the number of patients with <12 lymph node yield between those who received neoadjuvant therapy and those who did not (27.0%
conclusionsAlthough neoadjuvant therapy reduces the lymph node yield during surgery for locally advanced rectal cancer, this has no significance on the overall survival of the patient.
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