ArticleUnited European gastroenterology journal2019
Haemostasis and prevention of bleeding related to ER: The role of a novel self-assembling peptide.
Article in United European gastroenterology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05581173 (Multicenter Prospective Evaluation of the Efficacy of a Self-Assembling Matrix Forming Gel to Prevent Stricture Formation in High-Risk Patients), which is not on this map. Cited by 49 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Multicenter Prospective Evaluation of the Efficacy of a Self-Assembling Matrix Forming Gel to Prevent Stricture Formation in High-Risk Patients
Who cites it
49 citing papers in PubMed, 76 citations in OpenAlex.
- Hemostatic Efficacy and Safety of the Hybrid Injector ClearCoajet in Endoscopic Mucosal Resection of Large Colorectal Polyps: A Multicenter Randomized Trial.Digestive diseases and sciences · 2026Trial
- Use of the self-assembling peptide (PuraStat™) for the management and prevention of ERCP-related bleeding: a multicenter prospective cohort study.Surgical endoscopy · 2026Observational
- Cost-Effectiveness Analysis of Defect Closure Techniques After Conventional Endoscopic Mucosal Resection for Large Colon Polyps.Digestive diseases and sciences · 2026Article
- Precise and optimal delivery techniques of hemostatic powders in gastrointestinal bleeding.Clinical endoscopy · 2026Review
- Self-assembling peptide hydrogel prevents esophageal stenosis after endoscopic submucosal dissection for esophageal squamous cell carcinoma: Multicenter prospective study.Endoscopy international open · 2026Article
- Effect of a self-assembling peptide hydrogel on delayed bleeding following endoscopic sphincterotomy: Prospective pilot cohort study.Endoscopy international open · 2026Article
- In Situ Photoactivated Hydrogel Adhesive Dressings for Post Colon Polypectomies (PolypCures).bioRxiv : the preprint server for biology · 2025Article
- Novel hemostatic gel and powder as rescue agents for arterial bleeding related to lumen-apposing metal stent placement.Endoscopy · 2025Article
- RADA-16 Reduces Postoperative Epistaxis After Inferior Turbinate Submucosal Resection.The Laryngoscope · 2025Article
- Hemostasis: Role of PuraStatWorld journal of gastrointestinal endoscopy · 2025Article
- A clear approach: Hemostatic gel as a novel adjunct for pediatric upper gastrointestinal bleeding.JPGN reports · 2025Article
- Colorectal endoscopic submucosal dissection in the USA: The current state and future perspectives.DEN open · 2025Review
- Efficacy and applications for PuraStatWorld journal of gastrointestinal endoscopy · 2025Article
- Novel hemostatic adhesive powder to prevent delayed bleeding after endoscopic submucosal dissection in the GI tract: first U.S. multicenter experience.iGIE : innovation, investigation and insights · 2024Article
- Utility of a self-assembling peptide in the management of refractory hemorrhagic duodenal ulcers.Endoscopy · 2024Article
- Impact of Using Self-Assembling Peptide (PuraStat) on Anastomotic Ulcers-A Multicenter Case Series.ACG case reports journal · 2024Article
- Efficacy of novel endoscopic hemostatic agent for bleeding control and prevention: Results from a prospective, multicenter national registry.Endoscopy international open · 2024Article
- Current otolaryngologic applications of the novel self-assembling RADA-16 peptide matrix.Laryngoscope investigative otolaryngology · 2024Article
- Systematic review of self-assembling peptides as topical agents for treatment and prevention of gastrointestinal bleeding.Clinical endoscopy · 2024Article
- Spray coagulation reduces the use of hemostatic forceps for intraoperative bleeding in gastric endoscopic submucosal dissection.JGH open : an open access journal of gastroenterology and hepatology · 2024Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Endoscopic resection is now commonly used for removal of early gastrointestinal lesions. However, the risk of the procedure may be heightened by intraprocedural or delayed bleeding. A novel, self-assembling peptide (PuraStat®) was recently licensed for use as a haemostat. Objective: The aim of this study was to assess the efficacy and safety of this haemostat when used to control intraprocedural bleeding or to prevent delayed bleeding in endoscopic resection. Methods: PuraStat® was used on 100 patients undergoing endoscopic resection in a tertiary referral centre. The efficacy, safety, feasibility of use and delayed bleeding rates were measured. Results: Forty-eight oesophageal, 31 colorectal, 11 gastric and 10 duodenal procedures were included. The mean lesion size was 3.7 cm and 30% of the patients were on antithrombotic therapy. Intraprocedural bleeding occurred in 64%. PuraStat® was an effective haemostat in 75% of these cases. Only a small amount was required for haemostasis (mean = 1.76 ml) and it took on average 69.5 seconds to stop a bleed. The delayed bleeding rate was 3%. Conclusions: PuraStat® is an effective haemostat for use in controlling bleeds during endoscopic resection. It is safe, easy to use and did not interfere with the procedure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.