Evidence map›Paper›PMID 30788116›Full record

ArticleUnited European gastroenterology journal2019

Palliative endoscopic drainage of malignant stenosis of biliary confluence: Efficiency of multiple drainage approach to drain a maximum of liver segments.

Fabrice Caillol, Erwan Bories, Christophe Zemmour, Christian Pesenti, Jean Philippe Ratone, Marine Gilabert, Simon Launay, Marc Giovannini

Open access · bronzeAbstract read
In one paragraph

Article in United European gastroenterology journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Fabrice CaillolEndoscopy Unit, Paoli Calmettes Institute, Marseille, France.ORCID 0000-0002-4186-0942
Erwan BoriesEndoscopy Unit, Paoli Calmettes Institute, Marseille, France.
Christophe ZemmourStatistics Unit, Paoli Calmettes Institute, Marseille, France.
Christian PesentiEndoscopy Unit, Paoli Calmettes Institute, Marseille, France.
Jean Philippe RatoneEndoscopy Unit, Paoli Calmettes Institute, Marseille, France.
Marine GilabertOncology Unit, Paoli Calmettes Institute, Marseille, France.
Simon LaunayOncology Unit, Paoli Calmettes Institute, Marseille, France.
Marc GiovanniniEndoscopy Unit, Paoli Calmettes Institute, Marseille, France.
Institut Paoli-Calmettes · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and aim: More than 50% of the liver should be drained in case of unresectable hilar liver stenosis; however, it remains unclear if the use of several types of drainage (endoscopic retrograde cholangiography and pancreatography, percutaneous-biliary drainage, endoscopic ultrasound biliary drainage (EUS-BD)), allowing better drainage, has an impact on survival. The aim of our study was to evaluate the percentage of liver drained and its correlation on survival whatever the drainage technique used. Patients and methods: This study was a retrospective analysis of a prospective registry of patients with malignant drainage stenosis of the hilum. The quality of drainage was evaluated based on the percentage of liver segments drained, which was calculated by dividing the number of liver segments drained by the total number of liver segments. Drainage could be achieved via an endoscopic, EUS-guided or percutaneous route not associated with the procedure. Results: Sixty patients (38 men) were included from January 2015 to July 2016. The mean patient age was 69.84 years. Stenosis was classified as type II for 17 (29%) patients, type III for 20 (34%) patients, and type IV for 22 (37%) patients. Histology revealed cholangiocarcinoma for 26 (43%) patients, metastatic disease from colorectal cancer for 15 (25%) patients and another cancer for 19 (32%) patients. The median survival time was five (2.3-12.3) months.The percentage of liver segments drained had a significant prognostic impact on overall survival regardless of the technique used to drain the liver. The percentage of liver segments drained was dichotomized based on a threshold value of 80%, resulting in two groups (<80% and ≥80%). Univariate analysis of overall survival revealed that the patients with <80% of liver segments drained had significantly worse prognoses (hazard ratio (HR) = 3.25 (1.66-6.36), Conclusion: The survival of patients with malignant stenosis of the biliary confluence is highly correlated with the percentage of liver segments drained, regardless of the technique used.

Indexed as

Constriction, PathologicDrainageEndoscopy, Digestive SystemPalliative CareAgedAged, 80 and overBile DuctsCause of DeathFemaleHumansMaleMiddle AgedMortalityProportional Hazards ModelsROC Curvebiliary hilum stentingERCPEUS-guided biliary drainage of the liver hilumhilar stenosispalliative biliary drainage

Identifiers

PMID30788116
PMCPMC6374838
OpenAlexW2893048740

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.