Evidence map›Paper›PMID 30788085›Full record

ArticleJournal of extracellular vesicles2019

Extracellular vesicles derived from cancer-associated fibroblasts induce the migration and invasion of oral squamous cell carcinoma.

Mauricio Rocha Dourado, Johanna Korvala, Pirjo Åström, Carine Ervolino De Oliveira, Nilva K Cervigne, Luciana Souto Mofatto, Debora Campanella Bastos, Ana Camila Pereira Messetti, Edgard Graner, Adriana Franco Paes Leme and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of extracellular vesicles, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
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  5. Article
  6. Review
  7. Edge-rich Cu-NTheranostics · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Therapeutic Potential of Extracellular Vesicles in Oral Inflammation.International journal of molecular sciences · 2025
    Review
  12. Nanotherapies Based on ROS Regulation in Oral Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Mauricio Rocha DouradoDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.ORCID 0000-0002-0906-4153
Johanna KorvalaCancer and Translational Medicine Research Unit, Biocenter Oulu and Faculty of Medicine, University of Oulu, Oulu, Finland.
Pirjo ÅströmCancer and Translational Medicine Research Unit, Faculty of Medicine and Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland.
Carine Ervolino De OliveiraDepartment of Pathology and Parasitology, University of Alfenas, Alfenas, Brazil.
Nilva K CervigneDepartment of Morphology and Basic Pathology, Faculty of Medicine of Jundiai, Jundiai, Brazil.
Luciana Souto MofattoGenomics and Expression Laboratory, Department of Genetics, Evolution and Bioagents, Institute of Biology, University of Campinas, Piracicaba, Brazil.
Debora Campanella BastosDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Ana Camila Pereira MessettiDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Edgard GranerDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.
Adriana Franco Paes LemeBrazilian Biosciences National Laboratory, LNBio, CNPEM, Campinas, Brazil.
Ricardo D ColettaDepartment of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Brazil.ORCID 0000-0001-5285-3046
Tuula SaloCancer and Translational Medicine Research Unit, Faculty of Medicine and Medical Research Center Oulu, Oulu University Hospital, University of Oulu, Oulu, Finland.
Universidade Estadual de Campinas (UNICAMP) · BRBrazilian Center for Research in Energy and Materials · BRFaculdade de Medicina de Jundiaí · BROulu University Hospital · FIUniversidade Federal de Alfenas · BRUniversity of Helsinki · FIUniversity of Oulu · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As one of the most abundant constituents of the tumour microenvironment (TME), cancer-associated fibroblasts (CAF) display critical roles during tumour progression and metastasis. Multiple classes of molecules including growth factors, cytokines, proteases and extracellular matrix proteins, are produced by CAF to act as mediators of the stroma-tumour interactions. One of the main channels for this communication is associated with extracellular vesicles (EV), which are secreted particles loaded with protein and genetic information. In this study, we evaluated the effects of EV derived from CAF primary human cell lines (n = 5) on proliferation, survival, migration, and invasion of oral squamous cell carcinoma (OSCC) cells. As controls, EV from human primary-established normal oral fibroblasts (NOF, n = 5) were used. Our

Indexed as

Extracellular vesicles (EV)invasionmigrationoral cancer-associated fibroblasts (CAF)tumor microenvironment (TMV)

Identifiers

PMID30788085
PMCPMC6374932
OpenAlexW2915049489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.