ArticleNutrition research and practice2019
Walnut phenolic extracts reduce telomere length and telomerase activity in a colon cancer stem cell model.
Article in Nutrition research and practice, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Molecular Mechanisms of Dietary Compounds in Cancer Stem Cells from Solid Tumors: Insights into Colorectal, Breast, and Prostate Cancer.International journal of molecular sciences · 2025Review
- Review
- Dietary Walnuts Prevented Indomethacin-Induced Gastric Damage via AP-1 Transcribed 15-PGDH, Nrf2-Mediated HO-1, and n-3 PUFA-Derived Resolvin E1.International journal of molecular sciences · 2024Article
- The Role of Nut and Seed Consumption in Colorectal Cancer: A Narrative Review.Medicina (Kaunas, Lithuania) · 2022Review
- Dietary intake of walnut preventedJournal of clinical biochemistry and nutrition · 2021Article
- Polyphenols Extracted from Chinese Hickory (Applied sciences (Basel, Switzerland) · 2020Article
- Walnut polyphenol extracts inhibitJournal of clinical biochemistry and nutrition · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesTelomeres are located at the chromosomal ends and progressively shortened during each cell cycle. Telomerase, which is regulated by MATERIALS/
methodsCD133
resultsTelomere length of WPE-treated cells was significantly decreased in a dose-dependent manner (5.16 ± 0.13 at 0 µg/mL, 4.79 ± 0.12 at 10 µg/mL, 3.24 ± 0.08 at 20 µg/mL and 3.99 ± 0.09 at 40 µg/mL;
conclusionIn the present cell culture model, WPE reduced telomere maintenance, which may provide a mechanistic link to the effect of walnuts on the viability of colon CSCs.
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Registered trials
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