Evidence map›Paper›PMID 30788038›Full record

ArticleWorld journal of gastrointestinal oncology2019

Identification of patients with pancreatic adenocarcinoma due to inheritable mutation: Challenges of daily clinical practice.

Alexander Jp Fulton, Angela Lamarca, Christina Nuttall, Lynne McCallum, Rille Pihlak, Derek O'Reilly, Fiona Lalloo, Mairéad G McNamara, Richard A Hubner, Tara Clancy and 1 more

Abstract read
In one paragraph

Article in World journal of gastrointestinal oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Current status of inherited pancreatic cancer.Hereditary cancer in clinical practice · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alexander Jp FultonDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom.
Angela LamarcaDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom. angela.lamarca@christie.nhs.uk.
Christina NuttallDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom.
Lynne McCallumDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom.
Rille PihlakDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom.
Derek O'ReillyHepato-pancreato-biliary Surgical Department, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester M13 9WL, United Kingdom.
Fiona LallooManchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Saint Mary's Hospital, Manchester M13 9WL, United Kingdom.
Mairéad G McNamaraDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom.
Richard A HubnerDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom.
Tara ClancyManchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Saint Mary's Hospital, Manchester M13 9WL, United Kingdom.
Juan W ValleDepartment of Medical Oncology, The Christie NHS Foundation Trust, Manchester M204BX, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIdentification of germ-line mutations in pancreatic ductal adenocarcinoma (PDAC) could impact on patient/family.

aimTo assess the referral pathways for genetic consultations in PDAC.

methodsElectronic records of PDAC patients were reviewed retrospectively. Patients eligible for genetic consultation referral were identified following the European Registry of Hereditary Pancreatitis and Familial Pancreatic Cancer (EUROPAC) criteria.

resultsFour-hundred patients were eligible. Of 113 patients (28.3%) meeting EUROPAC criteria, 8.8% were referred for genetic opinion. Germ-line mutations were identified in 0.75% of the whole population.

conclusionEarlier referrals and increased awareness may be able to overcome the low rate of successful genetic appointments.

Indexed as

BRCAGenetic consultationGenetic counsellingGermlinePancreatic adenocarcinoma

Identifiers

PMID30788038
PMCPMC6379756

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.