ArticleAmerican journal of translational research2019
Postconditioning with inhaled hydrogen attenuates skin ischemia/reperfusion injury through the RIP-MLKL-PGAM5/Drp1 necrotic pathway.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Regulatory complexity and therapeutic targeting of the necroptosis network.Frontiers in immunology · 2026Review
- Hydrogen-Rich Saline Combined With Vacuum Sealing Drainage Promotes Wound Healing by Altering Biotin Metabolism.Journal of cellular and molecular medicine · 2025Article
- Identification and validation of protein biomarkers for predicting gastrointestinal stromal tumor recurrence.Computational and structural biotechnology journal · 2024Article
- Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases.International journal of biological sciences · 2023Review
- Empagliflozin activates JAK2/STAT3 signaling and protects cardiomyocytes from hypoxia/reoxygenation injury under high glucose conditions.Journal of thrombosis and thrombolysis · 2023Article
- Hydrogen-generating Si-based agent protects against skin flap ischemia-reperfusion injury in rats.Scientific reports · 2022Article
- Alda-1, an Aldehyde Dehydrogenase 2 Agonist, Improves Cutaneous Wound Healing by Activating Epidermal Keratinocytes via Akt/GSK-3β/β-Catenin Pathway.Aesthetic plastic surgery · 2022Article
- Effect of Co-transplanting Stromal Vascular Fraction-Gelatin and Platelet-Rich Fibrin on the Long-Term Maintenance of Fat Volume.Aesthetic plastic surgery · 2022Article
- Comparison of Volume Retention and Biocompatibility of Acellular Dermal Matrix/Hyaluronic Acid Filler to Autologous Fat Grafts in a Mouse Model.Aesthetic plastic surgery · 2022Article
- Study of the Effect of Hyperbaric Oxygen Therapy on the Viability of Dorsal Cutaneous Flaps in Tobacco-Exposed Rats.Aesthetic plastic surgery · 2022Article
- Alda-1, an Aldehyde Dehydrogenase 2 Agonist, Improves Cutaneous Wound Healing by Activating Epidermal Keratinocytes Via Akt/GSK-3β/β-Catenin Pathway.Aesthetic plastic surgery · 2022Article
- Hydrogen-rich saline alleviates early brain injury through inhibition of necroptosis and neuroinflammation via the ROS/HO-1 signaling pathway after traumatic brain injury.Experimental and therapeutic medicine · 2022Article
- PGAM5: A necroptosis gene associated with poor tumor prognosis that promotes cutaneous melanoma progression.Frontiers in oncology · 2022Article
- The Effect of Apocynin on Fat Graft Survival.Aesthetic plastic surgery · 2021Article
- Downregulation of phosphoglycerate mutase 5 improves microglial inflammasome activation after traumatic brain injury.Cell death discovery · 2021Article
- Necroptosis Underlies Hepatic Damage in a Piglet Model of Lipopolysaccharide-Induced Sepsis.Frontiers in immunology · 2021Article
- Article
- D-allose alleviates ischemia/reperfusion (I/R) injury in skin flap via MKP-1.Molecular medicine (Cambridge, Mass.) · 2020Article
- Implications of Necroptosis for Cardiovascular Diseases.Current medical science · 2019Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study explored the flap-protective effects of high concentrations of hydrogen (HCH) inhalation in a rat flap ischemia/reperfusion (I/R) injury model and the potential mechanism of necroptosis. Forty-five male Sprague-Dawley rats were randomly divided into three groups: SH, IR and HCH groups. After undergoing 3 h of I/R management, the surgery groups were treated with ambient air (SH and IR) and high concentrations of hydrogen (HCH). On the third postoperative day, blood perfusion in the flap was measured using Laser Doppler flowmeters. RIP1, RIP3, MLKL, PGAM5 and Drp1 were examined by immunological detection and RT-qPCR. Compared to the IR group, larger areas of the skin flaps from the SH and HCH groups survived and displayed more blood perfusion. RIP1, RIP3, MLKL, PGAM5 and Drp1 were expressed at high levels in the IR group, and their expression was significantly decreased in the HCH group. In the SH and HCH groups, the necrotic factors measured here showed similar expression levels, which were significantly lower than the levels in the IR group, indicating that HCH-mediated protective effects on rat skin I/R necrosis may be associated with the necrotic pathway.
Indexed as
Identifiers
30788005PMC6357323W2916380061What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.