ArticleAmerican journal of translational research2019
Downregulation of miR143/145 gene cluster expression promotes the aortic media degeneration process via the TGF-β1 signaling pathway.
Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Using Molecular Targets to Predict and Treat Aortic Aneurysms.Reviews in cardiovascular medicine · 2022Review
- The role of vascular smooth muscle cells in the development of aortic aneurysms and dissections.European journal of clinical investigation · 2022Review
- Non-coding RNAs in aortic dissection: From biomarkers to therapeutic targets.Journal of cellular and molecular medicine · 2020Review
- From air pollution to cardiovascular diseases: the emerging role of epigenetics.Molecular biology reports · 2020Review
- Review
- Bioinformatics Analysis Reveals MicroRNA-193a-3p Regulates ACTG2 to Control Phenotype Switch in Human Vascular Smooth Muscle Cells.Frontiers in genetics · 2020Article
- Identification of the molecular mechanisms associated with acute type A aortic dissection through bioinformatics methods.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aortic dissection (AD) is a serious threat to human health; however, the cause of this condition has not yet been fully elucidated. In this study, we found significantly increased expression of phospho-Smad2/3 and phospho-ERK in AD tissues and downregulated expression of miR143 and miR145 in AD tissues. Knockdown of the miR143/145 gene cluster induced phenotypic switching of vascular smooth muscle cells (VSMCs) and activation of the TGF-β1 signaling pathway. When the TFG-β1 signaling pathway was blocked by pretreatment with an LY364947 inhibitor, expression of miR143 and miR145, and VSMC phenotypic markers were not affected by knockdown of the miR143/145 gene cluster. Immunohistochemical staining of aortic tissues donated by AD patients and organ donors showed decrease alpha-smooth muscle actin (α-SMA) expression in pathological tissue, while osteopontin (OPN) expression increased and the arrangement of smooth muscle cells in the tunica media was dysregulated. In conclusion, our study suggests that downregulated expression of the miR143/145 gene cluster promotes phenotypic switching of VSMCs via the TGF-β1 signaling pathway. This may play an important role in the pathogenesis of AD.
Indexed as
Identifiers
30787994PMC6357338W2986640280What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.