Evidence map›Paper›PMID 30787988›Full record

ArticleAmerican journal of translational research2019

mKLRL1 regulates the maturation of dendritic cells and plays important roles in immune tolerance.

Guoyan Liu, Shulei Yin, Ping Li, Yanmei Han, Yuejuan Zheng, Yi Zhang, Shuxun Liu, Jiangyan Li, Ziyi Guo, Yijie Tao and 3 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of translational research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Guoyan LiuNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Shulei YinNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Ping LiNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Yanmei HanNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Yuejuan ZhengDepartment of Immunology and Microbiology, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
Yi ZhangNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Shuxun LiuNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Jiangyan LiNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Ziyi GuoNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Yijie TaoNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Huazhang AnNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Sheng XuNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Yizhi YuNational Key Laboratory of Medical Immunology and Institute of Immunology, Second Military Medical University Shanghai 200433, China.
Second Military Medical University · CNShanghai University of Traditional Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

KLRL1 is a member of C-type lectin-like receptors (CLEC) and preferentially expressed on the surface of immune cells. We have previously illustrated its inhibitory role in Natural killer (NK) cells. Though cloned from dendritic cells (DCs), its role in DCs has not been fully identified. Here, we found that mKLRL1 markedly decreased during DC maturation; mKLRL1-modifed DCs showed enhanced phagocytic capability and reduced ability to induce T cell proliferation, which mimics immature DCs. Further investigation revealed that IL-10 was indispensable for mKLRL1 to suppress DC maturation. And p38 activation was responsible for preferential IL-10 production. Pretreatment with mKLRL1-modified DCs protected mice from subsequently EAE induction, indicating a role in immune tolerance. Taken together, our results have revealed an inhibitory role of KLRL1 in mouse DCs.

Indexed as

C-type lectin-like receptorDendritic cellsimmune regulationinhibitory receptors

Identifiers

PMID30787988
PMCPMC6357304
OpenAlexW2992111516

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.