ArticleFrontiers in genetics2019
Identification of Pre-symptomatic Gene Signatures That Predict Resilience to Cognitive Decline in the Genetically Diverse AD-BXD Model.
Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Magnetic resonance microscopy maps widespread effects of Alzheimer's disease on brain structures and behavior in mice.Nature neuroscience · 2026Article
- Resilience mechanisms underlying Alzheimer's disease.Metabolic brain disease · 2025Review
- Software and pipelines for registration and analyses of rodent brain image data in reference atlas space.Frontiers in neuroinformatics · 2025Article
- Resistance and Resilience to Alzheimer's Disease.Cold Spring Harbor perspectives in medicine · 2024Review
- Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model.Communications biology · 2024Article
- The concept of resilience to Alzheimer's Disease: current definitions and cellular and molecular mechanisms.Molecular neurodegeneration · 2024Review
- Systems genetics identifies methionine as a high risk factor for Alzheimer's disease.Frontiers in neuroscience · 2024Article
- Article
- Detecting the effect of genetic diversity on brain composition in an Alzheimer's disease mouse model.bioRxiv : the preprint server for biology · 2023Article
- Translational approaches to understanding resilience to Alzheimer's disease.Trends in neurosciences · 2022Review
- New Insights on Gene by Environmental Effects of Drugs of Abuse in Animal Models Using GeneNetwork.Genes · 2022Article
- Oral nimodipine treatment has no effect on amyloid pathology or neuritic dystrophy in the 5XFAD mouse model of amyloidosis.PloS one · 2022Article
- Pursuit of precision medicine: Systems biology approaches in Alzheimer's disease mouse models.Neurobiology of disease · 2021Review
- Article
- Identifying the molecular systems that influence cognitive resilience to Alzheimer's disease in genetically diverse mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Transcriptional Signatures of Tau and Amyloid Neuropathology.Cell reports · 2020Article
- Animal Models of Psychosis in Alzheimer Disease.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2020Review
- Cognitive Reserve in Model Systems for Mechanistic Discovery: The Importance of Longitudinal Studies.Frontiers in aging neuroscience · 2020Review
- Regulation of intrinsic excitability: Roles for learning and memory, aging and Alzheimer's disease, and genetic diversity.Neurobiology of learning and memory · 2019Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Across the population, individuals exhibit a wide variation of susceptibility or resilience to developing Alzheimer's disease (AD). Identifying specific factors that promote resilience would provide insight into disease mechanisms and nominate potential targets for therapeutic intervention. Here, we use transcriptome profiling to identify gene networks present in the pre-symptomatic AD mouse brain relating to neuroinflammation, brain vasculature, extracellular matrix organization, and synaptic signaling that predict cognitive performance at an advanced age. We highlight putative drivers of these observed relationships, including
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.