Evidence map›Paper›PMID 30787641›Full record

ArticleClinical pharmacology : advances and applications2019

Assessing the effect of omega-3 fatty acid combined with vitamin D3 versus vitamin D3 alone on estradiol levels: a randomized, placebo-controlled trial in females with vitamin D deficiency.

Amani H Al-Shaer, Mahmoud S Abu-Samak, Luai Z Hasoun, Beisan A Mohammad, Iman A Basheti

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical pharmacology : advances and applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03333564 nacompletednot on this map

Effect of Vitamin D3 and Omega-3FA on Estradiol

TypeinterventionalSponsorApplied Science Private UniversityRan2016 to 2017Enrolled116ConditionsVitamin D DeficiencyArmsVD3, Omega3-FA, VD3 and Omega-3FA, Control
NCT04682626 nacompletednot on this mapstarted 2020, after this paper: background citation

Effect of Weekly High-dose Vitamin D3 Supplementation on the Association Between Circulatory FGF-23 and A1c Levels in People With Vitamin D Deficiency

TypeinterventionalSponsorApplied Science Private UniversityRan2020 to 2021Enrolled150ConditionsDiabetes Mellitus, Type 2, Kidney DiseasesArmsSoft gelatin capsules each contains 50 000 IU VD3 (cholecalciferol) equivalents to 1.25 mg.
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Amani H Al-ShaerDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan, m_abusamak@asu.edu.jo.
Mahmoud S Abu-SamakDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan, m_abusamak@asu.edu.jo.
Luai Z HasounDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan, m_abusamak@asu.edu.jo.
Beisan A MohammadDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan, m_abusamak@asu.edu.jo.
Iman A BashetiDepartment of Clinical Pharmacy and Therapeutics, Applied Science Private University, Amman, Jordan, m_abusamak@asu.edu.jo.
Applied Science Private University · JO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeOutcomes investigating the effect of vitamin D3 (VD3) and omega-3 fatty acids (Omega-3FA) on serum estradiol (E2) are scarce and conflicting. No previous study has investigated the effect of VD3 combination with Omega-3FA on E2 levels. This study was designed to investigate the effect of VD3, Omega-3FA and VD3 plus Omega-3FA on serum E2 levels in premenopausal females diagnosed with vitamin D deficiency (VDD). SUBJECTS AND

methodsThis randomized, placebo-controlled clinical trial was designed to evaluate the effects of 50,000 IU VD3 taken weekly, 300 mg Omega-3FA taken daily and their combination by the study participants for 8 weeks. The mid-follicular serum levels of E2 and 25-hydroxy vitamin D (25OHD) were assessed at 8 weeks. The study was conducted during winter on a convenience sample of healthy premenopausal Jordanian females with diagnosed VDD. Fasting serum levels for 25OHD and E2 were assessed at baseline and the end of the trial (after 8 weeks). Data were entered into SPSS and analyzed.

resultsHealthy premenopausal Jordanian females (N=86) with diagnosed VDD, mean age 32.8±8.9 years, were recruited into the study. Supplementation of VD3 alone resulted in a significant increase in serum 25OHD (13.4±7.9-28.2±7.1 ng/mL,

conclusionResults of this study provide vital insight into the effects of D3, Omega-3FA and a combination of their supplementation on premenopausal Jordanian females with diagnosed VDD. Eight weeks of therapy led to decreased E2 level by VD3 and increased level by Omega-3FA supplementation. With regard to 25OHD, its level was increased by VD3 and decreased by Omega-3FA supplementation. Combination of VD3 plus Omega-3FA increased the levels of both E2 and 25OHD.

trial registrationThis trial was registered at clinicaltrials.gov as NCT03333564.

Indexed as

canceromega-3 fatty acidspremenopausal femalesserum levels of estradiolvitamin D3vitamin D deficiency

Identifiers

PMID30787641
PMCPMC6366354
OpenAlexW2914620690

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.