ReviewEuropean journal of clinical nutrition2019
The role of dietary sugars in health: molecular composition or just calories?
Review in European journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Comparing body composition between the sweet-liking phenotypes: experimental data, systematic review and individual participant data meta-analysis.International journal of obesity (2005) · 2024Pooled it
- Trial
- In Vitro Testing of Artificial Sweeteners with Apple and Chokeberry Fruit Juice Extracts for Intestinal Permeability and Glucose Uptake.ACS omega · 2026Article
- Single-cell Raman imaging reveals fructose impairs brown adipocyte differentiation.Biosensors & bioelectronics · 2025Article
- Low- or No-Energy Sweeteners and Body Weight Management: Dissecting a "Minor" Effect.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025Review
- A Comparative Analysis of the Use of Low-Calorie and No-Calorie Sweeteners in Food Products Without and With Added Sugar on the Polish Market.Nutrients · 2025Article
- Activating the d-Tagatose Production Capacity ofJournal of agricultural and food chemistry · 2025Article
- Gut microbiota, nutrients, and depression.Frontiers in nutrition · 2025Review
- Optimization of the Fermentation Process and Sensory Evaluation of Wild Loquat (International journal of food science · 2025Article
- Review
- A high sucrose detection threshold is associated with increased energy intake and improved post-prandial glucose response independent of the sweetness intensity of isocaloric sucrose solutions.npj metabolic health and disease · 2024Article
- Review
- The Effect of Unrefined Sugar on Inflammation: A Systematic Review of Intervention Studies.International journal of preventive medicine · 2023Review
- Sweetness preference and its impact on energy intake and body weight - a review of evidence.Frontiers in nutrition · 2023Review
- Net gain and loss: influence of natural rewards and drugs of abuse on perineuronal nets.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Article
- Is Adolescents' Free Sugar Intake Associated with the Free Sugar Intake of Their Parents?Nutrients · 2022Article
- Maternal Fructose Intake, Programmed Mitochondrial Function and Predisposition to Adult Disease.International journal of molecular sciences · 2022Review
- Article
- The Proportion and Type of Carbohydrates in the Diets of Children in Early Adolescence.Materia socio-medica · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review will focus on the question of whether dietary sugars are a relevant determinant in the global rise of overweight and obesity in adults, adolescents, and children. Initially, the review describes the current definitions for sugars in the diet and makes reference to them while analyzing their role in overweight and obesity as well as diet-related diseases, including type 2 diabetes, cardiovascular diseases, non-alcoholic fatty liver disease and cancer. Second, it will focus particularly on sucrose and the question of whether it is the molecular composition of sucrose (glucose and fructose) or its energy content that promotes body weight gain and diet-related diseases. Finally, the review will clarify the molecular characteristics of sucrose regarding the release of the gastrointestinal glucose-dependent insulinotropic peptide (GIP) compared to other energy-providing nutrients and its relevance in metabolic diseases. Current data indicates that dietary sugars are only associated with an increase in obesity when consumed as an excess source of calories and with that an increase in the risk of diet-related diseases. Furthermore, it was shown that a diet rich in fat will stimulate GIP secretion more than a diet rich in sucrose. Taken together, current scientific evidence does not support the conclusion that dietary sugars per se are detrimental to human health.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.