ArticleScientific reports2019
Overexpression of thermostable meso-diaminopimelate dehydrogenase to redirect diaminopimelate pathway for increasing L-lysine production in Escherichia coli.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 17 citations in OpenAlex.
- Application and progress of synthetic biology technology in amino acid production.Bioprocess and biosystems engineering · 2026Review
- Metabolic engineering strategies of Corynebacterium glutamicum for sulfur-containing amino acid production: current progress and future directions.World journal of microbiology & biotechnology · 2026Review
- Functional and genomic profiling of lactic acid bacteria reveals specific traits as potential probiotics.Frontiers in microbiology · 2026Article
- Genetic "expiry-date" circuits control lifespan of synthetic scavenger bacteria for safe bioremediation.Nucleic acids research · 2025Article
- Dietary supplementation with isochlorogenic acid improves growth performance and intestinal health of broilers.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- OptimizingFrontiers in microbiology · 2024Review
- Description of Anaerostipes faecalis sp. nov., a new segmented filamentous bacterium isolated from swine faeces.Antonie van Leeuwenhoek · 2021Article
- A Computational Framework to Identify Metabolic Engineering Strategies for the Co-Production of Metabolites.Frontiers in bioengineering and biotechnology · 2021Article
- Identification and functional characterization of NAD(P)MicrobiologyOpen · 2020Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dehydrogenase pathway, one of diaminopimelate pathway, is important to the biosynthesis of L-lysine and peptidoglycan via one single reaction catalyzed by meso-diaminopimelate dehydrogenase (DapDH). In this study, the thermostable DapDH was introduced into diaminopimelate pathway that increased the final titer (from 71.8 to 119.5 g/L), carbon yield (from 35.3% to 49.1%) and productivity (from 1.80 to 2.99 g/(L∙h)) of L-lysine by LATR12-2∆rpiB::ddh
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