Evidence map›Paper›PMID 30787463›Full record

SynthesisBritish journal of cancer2019

Genome-wide association study of germline variants and breast cancer-specific mortality.

Maria Escala-Garcia, Qi Guo, Thilo Dörk, Sander Canisius, Renske Keeman, Joe Dennis, Jonathan Beesley, Julie Lecarpentier, Manjeet K Bolla, Qin Wang and 227 more

Open access · hybridAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in British journal of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 4 pooled it
9.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 4 syntheses or guidelines pooled it, 72 citations in OpenAlex.

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  17. Associations of a Breast Cancer Polygenic Risk Score With Tumor Characteristics and Survival.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

237 authors at 20 institutions in 23 countries.

Maria Escala-GarciaThe Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.
Qi GuoUniversity of Cambridge, Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, Cambridge, UK. qg209@medschl.cam.ac.uk.
Thilo DörkHannover Medical School, Gynaecology Research Unit, Hannover, Germany.
Sander CanisiusThe Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.
Renske KeemanThe Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.
Joe DennisUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.
Jonathan BeesleyQIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, Queensland, Australia.
Julie LecarpentierUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.
Manjeet K BollaUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.
Qin WangUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.
Jean AbrahamUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK.
Irene L AndrulisLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON, Canada.
Hoda Anton-CulverUniversity of California Irvine, Department of Epidemiology, Genetic Epidemiology Research Institute, Irvine, CA, USA.
Volker ArndtGerman Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.
Paul L AuerFred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA, USA.
Matthias W BeckmannUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
Sabine BehrensGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Javier BenitezSpanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain.
Marina BermishevaUfa Scientific Center of Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, Russia.
Leslie BernsteinBeckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA.
Carl BlomqvistUniversity of Helsinki, Department of Oncology, Helsinki University Hospital, Helsinki, Finland.
Bram BoeckxVIB, VIB Center for Cancer Biology, Leuven, Belgium.
Stig E BojesenCopenhagen University Hospital, Copenhagen General Population Study, Herlevand Gentofte Hospital, Herlev, Denmark.
Bernardo BonanniDivision of Cancer Prevention and Genetics, IEO, European Institute of Oncology IRCCS Milan, Milan, 20141, Italy.
Anne-Lise Børresen-DaleOslo University Hospital-Radiumhospitalet, Department of Cancer Genetics, Institute for Cancer Research, Oslo, Norway.
Hiltrud BrauchDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
Hermann BrennerGerman Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.
Adam BrentnallQueen Mary University of London, Centre for Cancer Prevention, Wolfson Institute of Preventive Medicine, London, UK.
Louise BrintonNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
Per BrobergLund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden.
Ian W BrockUniversity of Sheffield, Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, Sheffield, UK.
Sara Y BruckerUniversity of Tübingen, Department of Gynecology and Obstetrics, Tübingen, Germany.
Barbara BurwinkelUniversity of Heidelberg, Department of Obstetrics and Gynecology, Heidelberg, Germany.
Carlos CaldasCambridge Experimental Cancer Medicine Centre, Cambridge, UK.
Trinidad CaldésInstituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Cl'nico San Carlos, Madrid, Spain.
Daniele CampaGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Federico CanzianGerman Cancer Research Center (DKFZ), Molecular Epidemiology Group, C080, Heidelberg, Germany.
Angel CarracedoInstituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Genomic Medicine Group, Galician Foundation of Genomic Medicine, SERGAS, Santiago de Compostela, Spain.
Brian D CarterAmerican Cancer Society, Epidemiology Research Program, Atlanta, GA, USA.
Jose E CastelaoInstituto de Investigación Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Oncology and Genetics Unit, Vigo, Spain.
Jenny Chang-ClaudeGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Stephen J ChanockNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
Georgia Chenevix-TrenchQIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, Queensland, Australia.
Ting-Yuan David ChengRoswell Park Cancer Institute, Division of Cancer Prevention and Control, Buffalo, NY, USA.
Suet-Feung ChinUniversity of Cambridge, Cancer Research UK Cambridge Institute, Cambridge, UK.
Christine L ClarkeUniversity of Sydney, Westmead Institute for Medical Research, Sydney, NSW, Australia.
NBCS Collaborators
Emilie Cordina-DuvergerINSERM, University Paris-Sud, University Paris-Saclay, Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France.
Fergus J CouchMayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN, USA.
David G CoxImperial College London, Department of Epidemiology and Biostatistics, School of Public Health, London, UK.
Angela CoxUniversity of Sheffield, Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, Sheffield, UK.
Simon S CrossUniversity of Sheffield, Academic Unit of Pathology, Department of Neuroscience, Sheffield, UK.
Kamila CzeneKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.
Mary B DalyFox Chase Cancer Center, Department of Clinical Genetics, Philadelphia, PA, USA.
Peter DevileeLeiden University Medical Center, Department of Pathology, Leiden, The Netherlands.
Janet A DunnUniversity of Warwick, Warwick Clinical Trials Unit, Coventry, UK.
Alison M DunningUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK.
Lorraine DurcanUniversity of Southampton, Southampton Clinical Trials Unit, Faculty of Medicine, Southampton, UK.
Miriam DwekUniversity of Westminster, Department of Biomedical Sciences, Faculty of Science and Technology, London, UK.
Helena M EarlUniversity of Cambridge NHS Foundation Hospitals, Cambridge Breast Unit and NIHR Cambridge Biomedical Research Centre, Cambridge, UK.
Arif B EkiciFriedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-EMN, Institute of Human Genetics, University Hospital Erlangen, Erlangen, Germany.
A Heather EliassenHarvard Medical School, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Carolina EllbergLund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden.
Christoph EngelUniversity of Leipzig, Institute for Medical Informatics, Statistics and Epidemiology, Leipzig, Germany.
Mikael ErikssonKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.
D Gareth EvansUniversity of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK.
Jonine FigueroaNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
Dieter Flesch-JanysUniversity Medical Centre Hamburg-Eppendorf, Institute for Medical Biometrics and Epidemiology, Hamburg, Germany.
Henrik FlygerCopenhagen University Hospital, Department of Breast Surgery, Herlev and Gentofte Hospital, Herlev, Denmark.
Marike GabrielsonKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.
Manuela Gago-DominguezInstituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Genomic Medicine Group, Galician Foundation of Genomic Medicine, SERGAS, Santiago de Compostela, Spain.
Eva GalleVIB, VIB Center for Cancer Biology, Leuven, Belgium.
Susan M GapsturAmerican Cancer Society, Epidemiology Research Program, Atlanta, GA, USA.
Montserrat García-ClosasNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
José A García-SáenzInstituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Cl'nico San Carlos, Madrid, Spain.
Mia M GaudetAmerican Cancer Society, Epidemiology Research Program, Atlanta, GA, USA.
Angela GeorgeThe Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK.
Vassilios GeorgouliasUniversity Hospital of Heraklion, Department of Medical Oncology, Heraklion, Greece.
Graham G GilesCancer Council Victoria, Cancer Epidemiology & Intelligence Division, Melbourne, VIC, Australia.
Gord GlendonLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON, Canada.
David E GoldgarHuntsman Cancer Institute, University of Utah School of Medicine, Department of Dermatology, Salt Lake City, UT, USA.
Anna González-NeiraSpanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid, Spain.
Grethe I Grenaker AlnæsOslo University Hospital-Radiumhospitalet, Department of Cancer Genetics, Institute for Cancer Research, Oslo, Norway.
Mervi GripUniversity of Oulu, Department of Surgery, Oulu University Hospital, Oulu, Finland.
Pascal GuénelINSERM, University Paris-Sud, University Paris-Saclay, Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France.
Lothar HaeberleFriedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Centre Erlangen-EMN, Department of Gynaecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany.
Eric HahnenUniversity Hospital of Cologne, Centre for Hereditary Breast and Ovarian Cancer, Cologne, Germany.
Christopher A HaimanUniversity of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA.
Niclas HåkanssonKarolinska Institutet, Institute of Environmental Medicine, Stockholm, Sweden.
Per HallKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.
Ute HamannGerman Cancer Research Centre (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany.
Susan HankinsonUniversity of Massachusetts, Amherst, Department of Biostatistics & Epidemiology, Amherst, MA, USA.
Elaine F HarknessUniversity of Manchester, Manchester Academic Health Science Centre, Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, Manchester, UK.
Patricia A HarringtonUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK.
Steven N HartMayo Clinic, Department of Health Sciences Research, Rochester, MN, USA.
Jaana M HartikainenUniversity of Eastern Finland, Translational Cancer Research Area, Kuopio, Finland.
Alexander HeinUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
Peter HillemannsHannover Medical School, Gynaecology Research Unit, Hannover, Germany.
Louise HillerUniversity of Warwick, Warwick Clinical Trials Unit, Coventry, UK.
Bernd HolleczekSaarland Cancer Registry, Saarbruecken, Germany.
Antoinette HollestelleErasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands.
Maartje J HooningErasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands.
Robert N HooverNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
John L HopperThe University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, VIC, Australia.
Anthony HowellUniversity of Manchester, Institute of Cancer studies, Manchester, UK.
Guanmengqian HuangGerman Cancer Research Centre (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany.
Keith HumphreysKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm, Sweden.
David J HunterHarvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
Wolfgang JanniCancer Research UK Edinburgh Centre, Edinburgh, UK.
Esther M JohnCancer Prevention Institute of California, Department of Epidemiology, Fremont, CA, USA.
Michael E JonesInstitute of Cancer Research, Division of Genetics and Epidemiology, London, UK.
Arja Jukkola-VuorinenTampere University Hospital, Department of Oncology, Tampere, Finland.
Audrey JungGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Rudolf KaaksGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Maria KabischGerman Cancer Research Centre (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany.
Katarzyna KaczmarekPomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland.
Michael J KerinNational University of Ireland, Surgery, School of Medicine, Galway, Ireland.
Sofia KhanUniversity of Helsinki, Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland.
Elza KhusnutdinovaUfa Scientific Center of Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa, Russia.
Johanna I KiiskiUniversity of Helsinki, Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland.
Cari M KitaharaNational Cancer Institute, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
Julia A KnightLunenfeld-Tanenbaum Research Institute, Sinai Health System, Prosserman Centre for Population Health Research, Toronto, ON, Canada.
Yon-Dschun KoJohanniter Krankenhaus, Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Bonn, Germany.
Linetta B KoppertErasmus MC Cancer Institute, Department of Surgical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands.
Veli-Matti KosmaUniversity of Eastern Finland, Translational Cancer Research Area, Kuopio, Finland.
Peter KraftHarvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
Vessela N KristensenOslo University Hospital-Radiumhospitalet, Department of Cancer Genetics, Institute for Cancer Research, Oslo, Norway.
Ute KrügerLund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden.
Tabea KühlUniversity Medical Center Hamburg-Eppendorf, Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), Hamburg, Germany.
Diether LambrechtsVIB, VIB Center for Cancer Biology, Leuven, Belgium.
Loic Le MarchandUniversity of Hawaii Cancer Center, Epidemiology Program, Honolulu, HI, USA.
Eunjung LeeUniversity of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA, USA.
Flavio LejbkowiczCarmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel.
Lian LiTianjin Medical University Cancer Institute and Hospital, Department of Epidemiology, Tianjin, China.
Annika LindblomKarolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm, Sweden.
Sara LindströmUniversity of Washington School of Public Health, Department of Epidemiology, Seattle, WA, USA.
Martha LinetNational Cancer Institute, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
Jolanta LissowskaM. Sklodowska-Curie Cancer Centre, Oncology Institute, Department of Cancer Epidemiology and Prevention, Warsaw, Poland.
Wing-Yee LoDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany.
Sibylle LoiblGmbH, German Breast Group, Neu Isenburg, Germany.
Jan LubińskiPomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland.
Michael P LuxFriedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Centre Erlangen-EMN, Department of Gynaecology and Obstetrics, University Hospital Erlangen, Erlangen, Germany.
Robert J MacInnisCancer Council Victoria, Cancer Epidemiology & Intelligence Division, Melbourne, VIC, Australia.
Melanie MaierthalerGerman Cancer Research Center (DKFZ), Molecular Epidemiology Group, C080, Heidelberg, Germany.
Tom MaishmanUniversity of Southampton, Southampton Clinical Trials Unit, Faculty of Medicine, Southampton, UK.
Enes MakalicThe University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, VIC, Australia.
Arto MannermaaUniversity of Eastern Finland, Translational Cancer Research Area, Kuopio, Finland.
Mehdi ManoochehriGerman Cancer Research Centre (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany.
Siranoush ManoukianFondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Unit of Medical Genetics, Department of Medical Oncology and Haematology, Milan, Italy.
Sara MargolinKarolinska Institutet, Department of Clinical Science and Education, Sšdersjukhuset, Stockholm, Sweden.
Maria Elena MartinezUniversity of California San Diego, Moores Cancer Center, La Jolla, CA, USA.
Dimitrios MavroudisUniversity Hospital of Heraklion, Department of Medical Oncology, Heraklion, Greece.
Catriona McLeanThe Alfred Hospital, Anatomical Pathology, Melbourne, VIC, Australia.
Alfons MeindlLudwig Maximilian University of Munich, Department of Gynaecology and Obstetrics, Munich, Germany.
Pooja MiddhaGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.
Nicola MillerNational University of Ireland, Surgery, School of Medicine, Galway, Ireland.
Roger L MilneCancer Council Victoria, Cancer Epidemiology & Intelligence Division, Melbourne, VIC, Australia.
Fernando MorenoInstituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Cl'nico San Carlos, Madrid, Spain.
Anna Marie MulliganUniversity of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON, Canada.
Claire MulotINSERM UMR-S1147, Université Paris Sorbonne Cité, Paris, France.
Rami NassirUniversity of California Davis, Department of Biochemistry and Molecular Medicine, Davis, CA, USA.
Susan L NeuhausenBeckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA, USA.
William T NewmanUniversity of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK.
Sune F NielsenCopenhagen University Hospital, Copenhagen General Population Study, Herlevand Gentofte Hospital, Herlev, Denmark.
Børge G NordestgaardCopenhagen University Hospital, Copenhagen General Population Study, Herlevand Gentofte Hospital, Herlev, Denmark.
Aaron NormanMayo Clinic, Department of Health Sciences Research, Rochester, MN, USA.
Håkan OlssonLund University, Department of Cancer Epidemiology, Clinical Sciences, Lund, Sweden.
Nick OrrQueen's University Belfast, Centre for Cancer Research and Cell Biology, Belfast, Ireland, UK.
V Shane PankratzUniversity of New Mexico, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
Tjoung-Won Park-SimonHannover Medical School, Gynaecology Research Unit, Hannover, Germany.
Jose I A PerezHospital Monte Naranco, Servicio de Cirug'a General y Especialidades, Oviedo, Spain.
Clara Pérez-BarriosHospital Universitario Puerta de Hierro, Medical Oncology Department, Madrid, Spain.
Paolo PeterlongoThe FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, IFOM, Milan, Italy.
Christos PetridisKing's College London, Research Oncology, Guy's Hospital, London, UK.
Mila PinchevCarmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel.
Karoliona PrajzendancPomeranian Medical University, Department of Genetics and Pathology, Szczecin, Poland.
Ross PrenticeFred Hutchinson Cancer Research Center, Cancer Prevention Program, Seattle, WA, USA.
Nadege PresneauUniversity of Westminster, Department of Biomedical Sciences, Faculty of Science and Technology, London, UK.
Darya ProkofievaBashkir State University, Department of Genetics and Fundamental Medicine, Ufa, Russia.
Katri PylkäsUniversity of Oulu, Laboratory of Cancer Genetics and Tumour Biology, Cancer and Translational Medicine Research Unit, Biocentre Oulu, Oulu, Finland.
Brigitte RackLudwig Maximilian University of Munich, Department of Gynaecology and Obstetrics, Munich, Germany.
Paolo RadiceFondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan, Italy.
Dhanya RamachandranHannover Medical School, Gynaecology Research Unit, Hannover, Germany.
Gadi RennertCarmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel.
Hedy S RennertCarmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa, Israel.
Valerie RheniusUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK.
Atocha RomeroHospital Universitario Puerta de Hierro, Medical Oncology Department, Madrid, Spain.
Rebecca RoylanceUCLH Foundation Trust, Department of Oncology, London, UK.
Emmanouil SaloustrosUniversity Hospital of Larissa, Department of Oncology, Larissa, Greece.
Elinor J SawyerKing's College London, Research Oncology, Guy's Hospital, London, UK.
Daniel F SchmidtThe University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, VIC, Australia.
Rita K SchmutzlerUniversity Hospital of Cologne, Centre for Hereditary Breast and Ovarian Cancer, Cologne, Germany.
Andreas SchneeweissUniversity of Heidelberg, Department of Obstetrics and Gynecology, Heidelberg, Germany.
Minouk J SchoemakerThe Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK.
Fredrick SchumacherCase Western Reserve University, Department of Population and Quantitative Health Sciences, Cleveland, OH, USA.
Lukas SchwentnerCancer Research UK Edinburgh Centre, Edinburgh, UK.
Rodney J ScottJohn Hunter Hospital, Division of Molecular Medicine, Pathology North, Newcastle, NSW, Australia.
Christopher ScottMayo Clinic, Department of Health Sciences Research, Rochester, MN, USA.
Caroline SeynaeveErasmus MC Cancer Institute, Department of Medical Oncology, Family Cancer Clinic, Rotterdam, The Netherlands.
Mitul ShahUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge, UK.
Jacques SimardCentre Hospitalier Universitaire de Québec - Université Laval Research Centre, Genomics Centre, Québec City, QC, Canada.
Ann SmeetsUniversity Hospitals Leuven, Department of Surgical Oncology, Leuven, Belgium.
Christof SohnUniversity of Heidelberg, National Centre for Tumour Diseases, Heidelberg, Germany.
Melissa C SoutheyMonash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, Victoria, Australia.
Anthony J SwerdlowThe Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK.
Aline TalhoukBC Cancer Agency and University of British Columbia, British Columbia's Ovarian Cancer Research (OVCARE) Program, Vancouver General Hospital, Vancouver, BC, Canada.
Rulla M TamimiHarvard Medical School, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
William J TapperUniversity of Southampton, Faculty of Medicine, Southampton, UK.
Manuel R TeixeiraPortuguese Oncology Institute, Department of Genetics, Porto, Portugal.
Maria TengströmUniversity of Eastern Finland, Translational Cancer Research Area, Kuopio, Finland.
Mary Beth TerryColumbia University, Department of Epidemiology, Mailman School of Public Health, New York, NY, USA.
Kathrin ThöneUniversity Medical Center Hamburg-Eppendorf, Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), Hamburg, Germany.
Rob A E M TollenaarLeiden University Medical Centre, Department of Surgery, Leiden, The Netherlands.
Ian TomlinsonUniversity of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, UK.
Diana TorresGerman Cancer Research Centre (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg, Germany.
Thérèse TruongINSERM, University Paris-Sud, University Paris-Saclay, Cancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), Villejuif, France.
Constance TurmanHarvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
Clare TurnbullThe Institute of Cancer Research, Division of Genetics and Epidemiology, London, UK.
Hans-Ulrich UlmerFrauenklinik der Stadtklinik Baden-Baden, Baden-Baden, Germany.
Michael UntchHelios Clinics Berlin-Buch, Department of Gynaecology and Obstetrics, Berlin, Germany.
Celine VachonMayo Clinic, Department of Health Sciences Research, Rochester, MN, USA.
Christi J van AsperenLeiden University Medical Centre, Department of Clinical Genetics, Leiden, The Netherlands.
Ans M W van den OuwelandErasmus University Medical Centre, Department of Clinical Genetics, Rotterdam, The Netherlands.
Elke M van VeenUniversity of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester, UK.
Camilla WendtKarolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm, Sweden.
Alice S WhittemoreStanford University School of Medicine, Department of Health Research and Policy - Epidemiology, Stanford, CA, USA.
Walter WillettHarvard T.H. Chan School of Public Health, Department of Epidemiology, Boston, MA, USA.
Robert WinqvistUniversity of Oulu, Laboratory of Cancer Genetics and Tumour Biology, Cancer and Translational Medicine Research Unit, Biocentre Oulu, Oulu, Finland.
Alicja WolkKarolinska Institutet, Department of Environmental Medicine, Division of Nutritional Epidemiology, Stockholm, Sweden.
Xiaohong R YangNational Cancer Institute, Division of Cancer Epidemiology and Genetics, Bethesda, MD, USA.
Yan ZhangGerman Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.
Douglas F EastonUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.
Peter A FaschingUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen, Germany.
Heli NevanlinnaUniversity of Helsinki, Department of Obstetrics and Gynaecology, Helsinki University Hospital, Helsinki, Finland.
Diana M EcclesUniversity of Southampton, Cancer Sciences Academic Unit, Faculty of Medicine, Southampton, UK.
Paul D P PharoahUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge, UK.
Marjanka K SchmidtThe Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam, The Netherlands.
German Cancer Research Center · DEUniversity of Cambridge · GBThe University of Melbourne · AUInstitute of Cancer Research · GBKarolinska Institutet · SEUniversität Hamburg · DEAmerican Cancer Society · USBrigham and Women's Hospital · USHarvard University · USManchester Academic Health Science Centre · GBUniversity of Eastern Finland · FIUniversity of Helsinki · FIInserm · FRMedizinische Hochschule Hannover · DEGuy's Hospital · GBLeiden University · NLLund University · SEMount Sinai Hospital · CAOslo University Hospital · NORussian Academy of Sciences · RU

Funding

WORD PROCESSING CENTER--COREP30CA006927 · NCI · RESEARCH INST OF FOX CHASE CAN CTR · PI Dietmar J Kappes · 1985 to 2026
$138.8M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
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6 · The paper itself

Abstract

backgroundWe examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry.

methodsMeta-analyses included summary estimates based on Cox models of twelve datasets using ~10.4 million variants for 96,661 women with breast cancer and 7697 events (breast cancer-specific deaths). Oestrogen receptor (ER)-specific analyses were based on 64,171 ER-positive (4116) and 16,172 ER-negative (2125) patients. We evaluated the probability of a signal to be a true positive using the Bayesian false discovery probability (BFDP).

resultsWe did not find any variant associated with breast cancer-specific mortality at P < 5 × 10

conclusionsWe uncovered germline variants on chromosome 7 at BFDP < 15% close to genes for which there is biological evidence related to breast cancer outcome. However, the paucity of variants associated with mortality at genome-wide significance underpins the challenge in providing genetic-based individualised prognostic information for breast cancer patients.

Indexed as

Bayes TheoremBreast NeoplasmsChromosomes, Human, Pair 7FemaleGenetic VariationGenome-Wide Association StudyHumansPrognosisProportional Hazards ModelsReceptors, EstrogenWhite PeopleReceptors, Estrogen

Identifiers

PMID30787463
PMCPMC6461853
OpenAlexW2918113141

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