ArticleNature2019
MHC class II proteins mediate cross-species entry of bat influenza viruses.
Abstract read
In one paragraph
Article in Nature, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
105citing papers in PubMed, 1 pooled it
12.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
105 citing papers in PubMed, 1 synthesis or guideline pooled it, 143 citations in OpenAlex.
- Systematic review and meta-analysis of genome-wide pooled CRISPR screens to identify host factors involved in influenza A virus infection.Journal of virology · 2024Pooled it
- Roles of the M2 protein of influenza A virus.Virus genes · 2026Review
- The receptor landscape of influenza A viruses.Journal of virology · 2026Review
- Influenza.Nature reviews. Disease primers · 2026Review
- H5N1 influenza binding and cell entry via human class II MHC, and blocking by cross-reactive antibodies.bioRxiv : the preprint server for biology · 2026Article
- Defining the molecular interaction between influenza hemagglutinin and MHC-II.bioRxiv : the preprint server for biology · 2026Article
- Identification of GRP78 as a novel host factor that facilitates zoonotic porcine deltacoronavirus internalization and replication via clathrin-mediated endocytosis.Journal of virology · 2026Article
- Divergent pathogenic mechanisms of influenza A and influenza B viruses.Archives of microbiology · 2026Review
- Hemagglutinin double-mutation enhances binding of human-infecting avian influenza virus clade 2.3.4.4b H5Ny to human and SLeEMBO reports · 2026Article
- Rab11Bis required for binding and entry of recent H3N2, but not H1N1, influenza A isolates.Journal of virology · 2026Article
- USP17L13 Enhances Influenza a Virus Replication by Mediating the Degradation of RIG-I and MDA5.Viruses · 2026Article
- Quantifying and combating zoonotic viruses poised for emergence: Using multiplex receptor screening and decoy engineering technologies.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Genome-wide CRISPR/Cas9 knockout screen identifies host factors essential for bovine parainfluenza virus type 3 replication.Science China. Life sciences · 2026Article
- Influenza hemagglutinin subtypes have different sequence constraints despite sharing extremely similar structures.bioRxiv : the preprint server for biology · 2026Article
- MHC class II functions as a host-specific entry receptor for representative human and swine H3N2 influenza A viruses.Nature communications · 2026Article
- Influenza hemagglutinin subtypes have different sequence constraints despite sharing extremely similar structures.Virus evolution · 2026Article
- Protocol to measure the kinetics of MHC class II-influenza A binding using biolayer interferometry.STAR protocols · 2025Article
- Saffold virus exploits integrin αvβ8 and sulfated glycosaminoglycans as cooperative attachment receptors for infection.Nature communications · 2025Article
- A new path to spillover: MHC-II entry of influenza A viruses.PLoS biology · 2025Article
- Rab11B is required for binding and entry of recent H3N2, but not H1N1, influenza A isolates.bioRxiv : the preprint server for biology · 2025Article
45 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 9 institutions in 3 countries.
Umut Karakus *Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
Thiprampai Thamamongood *Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
Kevin CiminskiInstitute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
Wei RanInstitute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
Sira C GüntherInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Marie O PohlInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Davide ElettoInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Csaba JeneyDepartment of Microsystems Engineering - IMTEK, University of Freiburg, Freiburg, Germany.
Donata HoffmannInstitute of Diagnostic Virology, Friedrich-Loeffler Institut, Greifswald-Insel Riems, Germany.
Sven ReicheDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler Institut, Greifswald-Insel Riems, Germany.
Jan SchinkötheDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler Institut, Greifswald-Insel Riems, Germany.
Reiner UlrichDepartment of Experimental Animal Facilities and Biorisk Management, Friedrich-Loeffler Institut, Greifswald-Insel Riems, Germany.
Julius WienerHelmholtz Pioneer Campus, Helmholtz Zentrum Munich, Neuherberg, Germany.
Michael G B HayesDepartment of Medicine, University of California, San Diego, CA, USA.
Max W ChangDepartment of Medicine, University of California, San Diego, CA, USA.
Annika HunzikerInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Emilio YángüezInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Teresa AydilloDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Florian KrammerDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Josua OderbolzInstitute of Microbiology, ETH Zurich, Zurich, Switzerland.
Matthias MeierHelmholtz Pioneer Campus, Helmholtz Zentrum Munich, Neuherberg, Germany.
Annette OxeniusInstitute of Microbiology, ETH Zurich, Zurich, Switzerland.
Anne HaleniusInstitute of Virology, Medical Center University of Freiburg, Freiburg, Germany.
Gert ZimmerDivision of Virology, Institute of Virology and Immunology, Mittelhäusern, Switzerland.
Christopher BennerDepartment of Medicine, University of California, San Diego, CA, USA.
Benjamin G HaleInstitute of Medical Virology, University of Zurich, Zurich, Switzerland.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Martin BeerInstitute of Diagnostic Virology, Friedrich-Loeffler Institut, Greifswald-Insel Riems, Germany.
Martin Schwemmle *Institute of Virology, Medical Center University of Freiburg, Freiburg, Germany. martin.schwemmle@uniklinik-freiburg.de.
Silke Stertz *Institute of Medical Virology, University of Zurich, Zurich, Switzerland. stertz.silke@virology.uzh.ch.
University of Zurich · CHFriedrich-Loeffler-Institut · DEIcahn School of Medicine at Mount Sinai · USUniversity Medical Center Freiburg · DEUniversity of California, San Diego · USUniversity of Freiburg · DEETH Zurich · CHHelmholtz Zentrum München · DEUniversity of Bern · CH
Funding
SARS-CoV adaptations through a Systems Biology Lens (SYBIL)U19AI135972 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Adolfo Garcia-Sastre · 2018 to 2026
$27.2MNIAID NIH HHS HHSN272201400008C
Abstract
Zoonotic influenza A viruses of avian origin can cause severe disease in individuals, or even global pandemics, and thus pose a threat to human populations. Waterfowl and shorebirds are believed to be the reservoir for all influenza A viruses, but this has recently been challenged by the identification of novel influenza A viruses in bats
Indexed as
Host SpecificityAnimalsChickensChiropteraCRISPR-Associated Protein 9CRISPR-Cas SystemsFemaleGene Expression ProfilingHistocompatibility Antigens Class IIHLA-DR AntigensHumansInfluenza A virusMaleMiceMice, KnockoutRespiratory SystemCRISPR-Associated Protein 9Histocompatibility Antigens Class IIHLA-DR Antigens
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.