ArticleScientific reports2019
Viral metagenomics revealed novel betatorquevirus species in pediatric inpatients with encephalitis/meningoencephalitis from Ghana.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 45 citations in OpenAlex.
- Predictive Utility of ViroFind Detection of Blood and CSF Virome for Viral Presence in Human Brain Tissue.International journal of molecular sciences · 2026Article
- The impact of temperature and insect-specific viruses on the transmission of alphaviruses byMicrobiology spectrum · 2025Article
- Anellovirus species in the serum of acute febrile patients from Mato Grosso, central Western Brazil, 2019.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
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- Persistence, spillover, and evolution of co-occurring lineages of lymphocytic choriomeningitis virus.Virus evolution · 2025Article
- Genomic characterization ofMicrobiology resource announcements · 2024Article
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- The mysterious anelloviruses: investigating its role in human diseases.BMC microbiology · 2024Review
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- Metagenomic next-generation sequencing of cell-free DNA for the identification of viruses causing central nervous system infections.Microbiology spectrum · 2024Article
- Clinical epidemiology, determinants, and outcomes of viral encephalitis in Ghana; a cross-sectional study.PloS one · 2024Article
- Human Anelloviruses: Influence of Demographic Factors, Recombination, and Worldwide Diversity.Microbiology spectrum · 2023Article
- Discovery and comparative genomic analysis of a novel equine anellovirus, representing the first complete Mutorquevirus genome.Scientific reports · 2023Article
- Novel Virus Identification through Metagenomics: A Systematic Review.Life (Basel, Switzerland) · 2022Review
- Post-infantile Giant Cell Hepatitis: A Literature Review and Meta-analysis.Journal of clinical and translational pathology · 2022Article
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- Viruses associated with ill health in wild chimpanzees.American journal of primatology · 2022Article
- Metagenomic next-generation sequencing for identification of central nervous system pathogens in HIV-infected patients.Frontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cause of acute encephalitis/meningoencephalitis in pediatric patients remains often unexplained despite extensive investigations for large panel of pathogens. To explore a possible viral implication, we investigated the virome of cerebrospinal fluid specimens of 70 febrile pediatric inpatients with clinical compatible encephalitis/meningoencephalitis. Using viral metagenomics, we detected and genetically characterized three novel human Torque teno mini virus (TTMV) species (TTMV-G1-3). Phylogenetically, TTMV-G1-3 clustered in three novel monophyletic lineages within genus Betatorquevirus of the Anelloviridae family. TTMV-G1-3 were highly prevalent in diseased children, but absent in the healthy cohort which may indicate an association of TTMV species with febrile illness. With 2/3 detected malaria co-infection, it remains unclear if these novel anellovirus species are causative agents or increase disease severity by interaction with malaria parasites. The presence of the viruses 28 days after initiating antimalarial and/or antibiotic treatment suggests a still active viral infection likely as effect of parasitic and/or bacterial co-infection that may have initiated a modulated immune system environment for viral replication or a defective virus clearance. This study increases the current knowledge on the genetic diversity of TTMV and strengthens that human anelloviruses can be considered as biomarkers for strong perturbations of the immune system in certain pathological conditions.
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