ArticleScientific reports2019
A softening laminar electrode for recording single unit activity from the rat hippocampus.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Multi-Layer Brain-Mimicking Phantom for Replicating Dura and Pia Membrane Dimpling and Rupture Properties During Neural Interface Implantation.bioRxiv : the preprint server for biology · 2026Article
- Hippocampal recording with a soft microelectrode array in a cranial window imaging scheme: a validation study.Scientific reports · 2024Article
- Tentacle Microelectrode Arrays Uncover Soft Boundary Neurons in Hippocampal CA1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Flexible neural probes: a review of the current advantages, drawbacks, and future demands.Journal of Zhejiang University. Science. B · 2024Review
- A self-stiffening compliant intracortical microprobe.Biomedical microdevices · 2024Article
- Wireless closed-loop deep brain stimulation using microelectrode array probes.Journal of Zhejiang University. Science. B · 2024Review
- Commonly Overlooked Factors in Biocompatibility Studies of Neural Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Advancing the interfacing performances of chronically implantable neural probes in the era of CMOS neuroelectronics.Frontiers in neuroscience · 2023Review
- Large-scale, closed-loop interrogation of neural circuits underlying cognition.Trends in neurosciences · 2022Review
- Histological and electrophysiological evidence on the safe operation of a sharp-tip multimodal optrode during infrared neuromodulation of the rat cortex.Scientific reports · 2022Article
- Highly Stretchable Hydrogels as Wearable and Implantable Sensors for Recording Physiological and Brain Neural Signals.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Recent Progress in Materials Chemistry to Advance Flexible Bioelectronics in Medicine.Advanced materials (Deerfield Beach, Fla.) · 2022Review
- Stable softening bioelectronics: A paradigm for chronically viable ester-free neural interfaces such as spinal cord stimulation implants.Biomaterials · 2021Article
- Influence of Implantation Depth on the Performance of Intracortical Probe Recording Sites.Micromachines · 2021Article
- A comparison of insertion methods for surgical placement of penetrating neural interfaces.Journal of neural engineering · 2021Review
- A Parylene Neural Probe Array for Multi-Region Deep Brain Recordings.Journal of microelectromechanical systems : a joint IEEE and ASME publication on microstructures, microactuators, microsensors, and microsystems · 2020Article
- Multi-layer brain-mimicking phantom for replicating dura and pia membrane dimpling and rupture properties during neural interface implantation.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Softening neural implants that change their elastic modulus under physiological conditions are promising candidates to mitigate neuroinflammatory response due to the reduced mechanical mismatch between the artificial interface and the brain tissue. Intracortical neural probes have been used to demonstrate the viability of this material engineering approach. In our paper, we present a robust technology of softening neural microelectrode and demonstrate its recording performance in the hippocampus of rat subjects. The 5 mm long, single shank, multi-channel probes are composed of a custom thiol-ene/acrylate thermoset polymer substrate, and were micromachined by standard MEMS processes. A special packaging technique is also developed, which guarantees the stable functionality and longevity of the device, which were tested under in vitro conditions prior to animal studies. The 60 micron thick device was successfully implanted to 4.5 mm deep in the hippocampus without the aid of any insertion shuttle. Spike amplitudes of 84 µV peak-to-peak and signal-to-noise ratio of 6.24 were achieved in acute experiments. Our study demonstrates that softening neural probes may be used to investigate deep layers of the rat brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.