Evidence map›Paper›PMID 30787325›Full record

ArticleNature communications2019

Genetic programming of macrophages generates an in vitro model for the human erythroid island niche.

Martha Lopez-Yrigoyen, Cheng-Tao Yang, Antonella Fidanza, Luca Cassetta, A Helen Taylor, Angela McCahill, Erica Sellink, Marieke von Lindern, Emile van den Akker, Joanne C Mountford and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 67 citations in OpenAlex.

  1. Orai1 acts as a novel CaExperimental & molecular medicine · 2026
    Article
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  5. Erythroblast enucleation at a glance.Journal of cell science · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Martha Lopez-YrigoyenMRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.ORCID http://orcid.org/0000-0002-5115-3942
Cheng-Tao YangMRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
Antonella FidanzaMRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
Luca CassettaMRC Centre for Reproductive Health, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.ORCID http://orcid.org/0000-0002-7913-935X
A Helen TaylorMRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK.
Angela McCahillScottish National Blood Transfusion Service, The Jack Copland Centre, 52 Research Avenue North, Heriot-Watt Research Park, Edinburgh, EH14 4BE, UK.
Erica SellinkSanquin Research, Department of Hematopoiesis, The Netherlands and Landsteiner Laboratory, Academic University Medical Cente, University of Amsterdam, Amsterdam, The Netherlands.
Marieke von LindernSanquin Research, Department of Hematopoiesis, The Netherlands and Landsteiner Laboratory, Academic University Medical Cente, University of Amsterdam, Amsterdam, The Netherlands.
Emile van den AkkerSanquin Research, Department of Hematopoiesis, The Netherlands and Landsteiner Laboratory, Academic University Medical Cente, University of Amsterdam, Amsterdam, The Netherlands.
Joanne C MountfordScottish National Blood Transfusion Service, The Jack Copland Centre, 52 Research Avenue North, Heriot-Watt Research Park, Edinburgh, EH14 4BE, UK.ORCID http://orcid.org/0000-0003-2142-6572
Jeffrey W PollardMRC Centre for Reproductive Health, University of Edinburgh, Queens Medical Research Institute, 47 Little France Crescent, Edinburgh, EH16 4TJ, UK.ORCID http://orcid.org/0000-0003-4579-0053
Lesley M ForresterMRC Centre for Regenerative Medicine, University of Edinburgh, 5 Little France Drive, Edinburgh, EH16 4UU, UK. L.Forrester@ed.ac.uk.ORCID http://orcid.org/0000-0002-9717-8299
MRC Centre for Regenerative Medicine · GBSanquin · NLMRC Centre for Reproductive Health · GBScottish National Blood Transfusion Service · GB

Funding

Medical Research Council G1002033Medical Research Council MR/K017047/1Medical Research Council MR/N022556/1Wellcome Trust
6 · The paper itself

Abstract

Red blood cells mature within the erythroblastic island (EI) niche that consists of specialized macrophages surrounded by differentiating erythroblasts. Here we establish an in vitro system to model the human EI niche using macrophages that are derived from human induced pluripotent stem cells (iPSCs), and are also genetically programmed to an EI-like phenotype by inducible activation of the transcription factor, KLF1. These EI-like macrophages increase the production of mature, enucleated erythroid cells from umbilical cord blood derived CD34

Indexed as

Angiopoietin-Like Protein 7Angiopoietin-like ProteinsAntigens, CD34Blood SubstitutesBlood TransfusionErythroblastsErythrocytesErythropoiesisHematopoietic Stem CellsHumansInduced Pluripotent Stem CellsInterleukin-33Kruppel-Like Transcription FactorsMacrophagesPlasminogen Activator Inhibitor 2Angiopoietin-Like Protein 7Angiopoietin-like ProteinsANGPTL7 protein, humanAntigens, CD34Blood Substituteserythroid Kruppel-like factorIL33 protein, humanInterleukin-33Kruppel-Like Transcription FactorsPlasminogen Activator Inhibitor 2

Identifiers

PMID30787325
PMCPMC6382809
OpenAlexW2915423594

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.