ArticleNature communications2019
The indirect health effects of malaria estimated from health advantages of the sickle cell trait.
Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Is sickle cell trait truly benign? A case-control study of physical and mental health outcomes from the sickle cell belt of Eastern India.Journal of community genetics · 2026Article
- Incidence of clinical malaria and asymptomatic parasitaemia among African children living with sickle cell disease: a multicentre prospective longitudinal cohort study protocol.BMJ public health · 2026Article
- Early-life clinical and hematological profiles: a comparative study of children with and without sickle cell disease in the first three years of life.Annals of hematology · 2025Article
- Sickle cell allele HBB-rs334(T) is associated with decreased risk of childhood Burkitt lymphoma in East Africa.American journal of hematology · 2024Article
- Article
- Improving the diagnosis of severe malaria in African children using platelet counts and plasmaScience translational medicine · 2022Article
- Confronting Racism in Pain Research: A Call to Action.The journal of pain · 2022Article
- Filling the data gaps on sickle cell anaemia in sub-Saharan Africa.The Lancet. Haematology · 2022Article
- Phthalimide analogs for antimalarial drug discovery.RSC medicinal chemistry · 2021Review
- Incidence and predictors of hospital readmission in children presenting with severe anaemia in Uganda and Malawi: a secondary analysis of TRACT trial data.BMC public health · 2021Article
- Article
- Malaria is a cause of iron deficiency in African children.Nature medicine · 2021Article
- Glucose-6-phosphate dehydrogenase deficiency and susceptibility to childhood diseases in Kilifi, Kenya.Blood advances · 2020Article
- Risk of pneumococcal bacteremia in Kenyan children with glucose-6-phosphate dehydrogenase deficiency.BMC medicine · 2020Article
- A common polymorphism in the mechanosensitive ion channelProceedings of the National Academy of Sciences of the United States of America · 2020Observational
- 5-(Hydroxymethyl)furfural restores low-oxygen rheology of sickle trait blood in vitro.British journal of haematology · 2020Article
- Life-Threatening Infectious Complications in Sickle Cell Disease: A Concise Narrative Review.Frontiers in pediatrics · 2020Review
- The epidemiology of sickle cell disease in children recruited in infancy in Kilifi, Kenya: a prospective cohort study.The Lancet. Global health · 2019Article
- Dehydrated hereditary stomatocytosis: clinical perspectives.Journal of blood medicine · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 1 institution in 2 countries.
Funding
Abstract
Most estimates of the burden of malaria are based on its direct impacts; however, its true burden is likely to be greater because of its wider effects on overall health. Here we estimate the indirect impact of malaria on children's health in a case-control study, using the sickle cell trait (HbAS), a condition associated with a high degree of specific malaria resistance, as a proxy indicator for an effective intervention. We estimate the odds ratios for HbAS among cases (all children admitted to Kilifi County Hospital during 2000-2004) versus community controls. As expected, HbAS protects strongly against malaria admissions (aOR 0.26; 95%CI 0.22-0.31), but it also protects against other syndromes, including neonatal conditions (aOR 0.79; 0.67-0.93), bacteraemia (aOR 0.69; 0.54-0.88) and severe malnutrition (aOR 0.67; 0.55-0.83). The wider health impacts of malaria should be considered when estimating the potential added benefits of effective malaria interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.