Evidence map›Paper›PMID 30787278›Full record

ArticleCell death & disease2019

circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis.

Jian-Zhen Xu, Chang-Chun Shao, Xiao-Jia Wang, Xing Zhao, Jun-Qing Chen, Yan-Xiu Ouyang, Jun Feng, Fan Zhang, Wen-He Huang, Qian Ying and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 165 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
165citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

165 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  5. Article
  6. Review
  7. Upregulation of a CircularInternational journal of molecular sciences · 2026
    Article
  8. Article
  9. Estradiol Promotes Endometriosis ProgressionCurrent pharmaceutical biotechnology · 2026
    Article
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105 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jian-Zhen XuDepartment of Bioinformatics, Shantou University Medical College (SUMC), 515041, Shantou, China. jzxu01@stu.edu.cn.
Chang-Chun ShaoChangJiang Scholar's Laboratory, Shantou University Medical College, 515041, Shantou, China.
Xiao-Jia WangKey Lab of Diagnosis & Treatment Technology on Thoracic Oncology, Zhejiang Cancer Hospital, 310000, Hangzhou, China.
Xing ZhaoDepartment of Bioinformatics, Shantou University Medical College (SUMC), 515041, Shantou, China.
Jun-Qing ChenKey Lab of Diagnosis & Treatment Technology on Thoracic Oncology, Zhejiang Cancer Hospital, 310000, Hangzhou, China.
Yan-Xiu OuyangChangJiang Scholar's Laboratory, Shantou University Medical College, 515041, Shantou, China.
Jun FengChangJiang Scholar's Laboratory, Shantou University Medical College, 515041, Shantou, China.
Fan ZhangGuangdong Provincial Key Laboratory on Breast Cancer Diagnosis and Treatment, Cancer Hospital of Shantou University Medical College, 515041, Shantou, China.
Wen-He HuangThe Breast Center, Cancer Hospital of Shantou University Medical College, 515041, Shantou, China.
Qian YingKey Lab of Diagnosis & Treatment Technology on Thoracic Oncology, Zhejiang Cancer Hospital, 310000, Hangzhou, China.
Chun-Fa ChenDepartment of Thyroid and Breast Surgery, First Affiliated Hospital of Shantou University Medical College, 515041, Shantou, China.
Xiao-Long WeiDepartment of Pathology, Cancer Hospital of Shantou University Medical College, 515041, Shantou, China.
Hong-Yan DongDepartment of Pathology, Linyi People's Hospital, 276000, Linyi, China.
Guo-Jun ZhangChangJiang Scholar's Laboratory, Shantou University Medical College, 515041, Shantou, China. guoj_zhang@yahoo.com.
Min ChenChangJiang Scholar's Laboratory, Shantou University Medical College, 515041, Shantou, China. mchen@xah.xmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

More and more evidence indicates that circular RNAs (circRNAs) have important roles in several diseases, especially in cancers. However, their involvement remains to be investigated in breast cancer. Through screening circRNA profile, we identified 235 differentially expressed circRNAs in breast cancer. Subsequently, we explored the clinical significance of two circTADA2As in a large cohort of triple-negative breast cancer (TNBC), and performed functional analysis of circTADA2A-E6 in vitro and in vivo to support clinical findings. Finally, we evaluated the effect of circTADA2A-E6 on miR-203a-3p and its target gene SOCS3. We detected two circRNAs, circTADA2A-E6 and circTADA2A-E5/E6, which were among the top five differentially expressed circRNAs in breast cancer. They were consistently and significantly decreased in a large cohort of breast cancer patients, and their downregulation was associated with poor patient survival for TNBC. Especially, circTADA2A-E6 suppressed in vitro cell proliferation, migration, invasion, and clonogenicity and possessed tumor-suppressor capability. circTADA2A-E6 preferentially acted as a miR-203a-3p sponge to restore the expression of miRNA target gene SOCS3, resulting in a less aggressive oncogenic phenotype. circTADA2As as promising prognostic biomarkers in TNBC patients, and therapeutic targeting of circTADA2As/miRNA/mRNA network may be a potential strategy for the treatment of breast cancer.

Indexed as

AnimalsCell MovementCell ProliferationDisease ProgressionDNA-Binding ProteinsDown-RegulationFemaleGene Expression Regulation, NeoplasticHEK293 CellsHumansLymphatic MetastasisMCF-7 CellsMiceMice, NudeMicroRNAsMiddle AgedDNA-Binding ProteinsMicroRNAsMIRN203 microRNA, humanRNA, CircularRNA, Small InterferingSOCS3 protein, humanSuppressor of Cytokine Signaling 3 ProteinTADA2A protein, humanTranscription Factors

Identifiers

PMID30787278
PMCPMC6382814

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.