ArticleScience translational medicine2019
The nonlesional skin surface distinguishes atopic dermatitis with food allergy as a unique endotype.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04662619 (A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled, Two-Arm, Parallel-Group, Nutritional Intervention Study to Examine the Clinical and Immunological Effects of a Probiotic Food Supplement Containing B. Infantis), which is not on this map. Cited by 101 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 1 pooled it
25.3field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Proof-of-Concept, Randomized, Double-Blind, Placebo-Controlled, Two-Arm, Parallel-Group, Nutritional Intervention Study to Examine the Clinical and Immunological Effects of a Probiotic Food Supplement Containing B. Infantis (EVC001) in Healthy Breastfed Infants at Risk of Developing Atopic Dermatitis
Who cites it
101 citing papers in PubMed, 1 synthesis or guideline pooled it, 216 citations in OpenAlex.
- Achieving Precision Medicine in Allergic Disease: Progress and Challenges.Frontiers in immunology · 2021Pooled it
- Transepidermal Water Loss in Oral Food Challenges in Children With Peanut Allergy: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Enhancement of stratum corneum lipid structure improves skin barrier function and protects against irritation in adults with dry, eczema-prone skin.The British journal of dermatology · 2022Trial
- Skin tape proteomics identifies pathways associated with transepidermal water loss and allergen polysensitization in atopic dermatitis.The Journal of allergy and clinical immunology · 2020Trial
- Simultaneous skin biome and keratinocyte genomic capture reveals microbiome differences by depth of sampling.The Journal of allergy and clinical immunology · 2020Trial
- Shotgun Metagenomics Reveals Skin Microbiome Composition and Function in Infant Atopic Disease.Allergy · 2026Article
- Skin Tape Stripping: A Non-Invasive Approach Linking Epidermal Changes and Systemic Inflammation in Atopic Dermatitis.Clinical and translational allergy · 2026Review
- Comparison of baseline TEWL values in OFC positive and negative patients.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Article
- Itching to know: the Microbiome, Allergic Disease, and Antimicrobial Chemicals.Current environmental health reports · 2026Review
- Basophils in Skin-Mediated Sensitization Drive Subsequent Lung Inflammation in Airway-Challenged Mice.Allergy · 2026Article
- Article
- Detection of Anaphylaxis Through the Cutaneous Barrier.Current allergy and asthma reports · 2025Review
- Decoding Early Clues: Immune Mechanisms, Prevention, Diagnosis, and Treatment of IgE-Mediated Peanut and Tree Nut Allergy in Children.Biomedicines · 2025Review
- Lebrikizumab Rapidly Lowers Inflammatory Biomarkers with Clinical Correlations in Moderate-to-Severe Atopic Dermatitis.Dermatology and therapy · 2025Article
- Epicutaneous Staphylococcus aureus initiates cross-tissue IL-36R signaling for neutrophilic lung inflammation in a model of the atopic march.Cell reports · 2025Article
- Multiomic approaches for endotype discovery in allergy/immunology.The Journal of allergy and clinical immunology · 2025Article
- Biomarker-driven drug development for allergic diseases and asthma: An FDA public workshop.The Journal of allergy and clinical immunology · 2025Article
- Biomarkers in Atopic Dermatitis in Children: A Comprehensive Review.Life (Basel, Switzerland) · 2025Review
- Recurrence and influencing factors of moderate-to-severe atopic dermatitis after dupilumab withdrawal: a retrospective cohort analysis.Frontiers in medicine · 2025Article
- Characterization of the Gut and Skin Microbiome over Time in Young Children with IgE-Mediated Food Allergy.Nutrients · 2024Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 5 institutions in 1 country.
Donald Y M LeungNational Jewish Health, Denver, CO 80206, USA. leungd@njhealth.org.ORCID 0000-0002-0177-3844
Agustin CalatroniRho Federal Systems Division Inc., Chapel Hill, NC 27517, USA.ORCID 0000-0002-1738-5176
Livia S ZaramelaUniversity of California, San Diego, La Jolla, CA 92093, USA.
Petra K LeBeauRho Federal Systems Division Inc., Chapel Hill, NC 27517, USA.ORCID 0000-0002-0883-9922
Nathan DyjackNational Jewish Health, Denver, CO 80206, USA.ORCID 0000-0001-6944-6252
Kanwaljit BrarNational Jewish Health, Denver, CO 80206, USA.
Gloria DavidRho Federal Systems Division Inc., Chapel Hill, NC 27517, USA.
Keli JohnsonRho Federal Systems Division Inc., Chapel Hill, NC 27517, USA.
Susan LeungNational Jewish Health, Denver, CO 80206, USA.
Marco Ramirez-GamaNational Jewish Health, Denver, CO 80206, USA.ORCID 0000-0003-4572-6115
Bo LiangUniversity of California, San Diego, La Jolla, CA 92093, USA.ORCID 0000-0002-1646-3013
Cydney RiosNational Jewish Health, Denver, CO 80206, USA.
Michael T MontgomeryNational Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-6748-2329
Brittany N RichersNational Jewish Health, Denver, CO 80206, USA.
Clifton F HallNational Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-5180-1014
Kathryn A NorquestNational Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-8834-2667
John JungNational Jewish Health, Denver, CO 80206, USA.
Irina BronovaNational Jewish Health, Denver, CO 80206, USA.
Simion KreimerJohns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0001-6627-3771
C Conover TalbotJohns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-3758-2425
Debra CrumrineUniversity of California, San Francisco, San Francisco, CA 94121, USA.
Robert N ColeJohns Hopkins University, Baltimore, MD 21218, USA.ORCID 0000-0002-3096-4754
Peter EliasUniversity of California, San Francisco, San Francisco, CA 94121, USA.
Karsten ZenglerUniversity of California, San Diego, La Jolla, CA 92093, USA.
Max A SeiboldNational Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-8685-4263
Evgeny BerdyshevNational Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-1376-0098
Elena GolevaNational Jewish Health, Denver, CO 80206, USA.ORCID 0000-0002-4685-9318
National Jewish Health · USRho (United States) · USJohns Hopkins University · USUniversity of California San Diego · USUniversity of California, San Francisco · US
Funding
Transplantation GroupUM2AI117870 · NIAID · RHO FEDERAL SYSTEMS DIVISION, INC. · PI DAVID, GLORIA · 2015 to 2023
$208.1MNIH Prior Approval Process ProfessionalUL1TR002535 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2018 to 2022
$51.1MTargeted Microbiome Transplant in Atopic DermatitisU19AI117673 · NIAID · NATIONAL JEWISH HEALTH · PI LEUNG, DONALD YM · 2015 to 2019
$30.6MSEAL (Stopping Atopic dermatitis and ALlergy) Study: Prevent allergy by enhancing the skin barrierU01AI147462 · NIAID · STANFORD UNIVERSITY · PI Mary Johnson, GIDEON LACK · 2020 to 2026
$14.0MTranscriptomic and Genetic Endotyping of Exacerbation-Prone AsthmaticsP01HL132821 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2017 to 2021
$9.0MTHE ROLE OF BACTERIAL TOXINS IN HUMAN SKIN DISEASER01AR041256 · NIAMS · NATIONAL JEWISH HEALTH · PI GOLEVA, ELENA, LEUNG, DONALD YM · 1992 to 2020
$5.9MTranscriptomic and Pharmacogenetic Asthma Endotypes in Minority ChildrenR01HL135156 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A, ZIV, ELAD · 2017 to 2021
$4.1MGenes, air pollution, and asthma severity in minority childrenR01MD010443 · NIMHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SEIBOLD, MAX A, ZIV, ELAD · 2016 to 2020
$3.8MGenetic Control of Airway Epithelium Gene Expression in Childhood AsthmaticsR01HL128439 · NHLBI · NATIONAL JEWISH HEALTH · PI SEIBOLD, MAX A · 2015 to 2019
$3.1MNCATS NIH HHS UL1 TR002535NHLBI NIH HHS P01 HL132821NHLBI NIH HHS R01 HL128439NHLBI NIH HHS R01 HL135156NIAID NIH HHS U01 AI147462NIAID NIH HHS U19 AI117673NIAID NIH HHS UM2 AI117870NIAMS NIH HHS R01 AR041256NIMHD NIH HHS R01 MD010443
Abstract
Skin barrier dysfunction has been reported in both atopic dermatitis (AD) and food allergy (FA). However, only one-third of patients with AD have FA. The purpose of this study was to use a minimally invasive skin tape strip sampling method and a multiomics approach to determine whether children with AD and FA (AD
Indexed as
AdolescentArea Under CurveChildChild, PreschoolDendritic CellsDermatitis, AtopicEpidermisFilaggrin ProteinsFood HypersensitivityHumansIntermediate Filament ProteinsKeratinsLipidsMicrobiotaSkinSurgical TapeFilaggrin ProteinsFLG protein, humanIntermediate Filament ProteinsKeratinsLipids
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT04662619ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.