Evidence map›Paper›PMID 30787033›Full record

ArticleThe Journal of experimental medicine2019

A major role for ferroptosis in

Eduardo P Amaral, Diego L Costa, Sivaranjani Namasivayam, Nicolas Riteau, Olena Kamenyeva, Lara Mittereder, Katrin D Mayer-Barber, Bruno B Andrade, Alan Sher

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of experimental medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 267 papers.

0numbers the graph read from it
0cells of the map it votes in
267citing papers in PubMed
26.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

267 citing papers in PubMed, 439 citations in OpenAlex.

  1. Review
  2. Ferroptosis in health and disease.Molecular biomedicine · 2026
    Review
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  18. Modulation of Ferroptosis During EarlybioRxiv : the preprint server for biology · 2026
    Article
  19. Article
  20. Article

207 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 4 countries.

Eduardo P AmaralImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD eduardo.amaral@nih.gov.ORCID 0000-0001-5465-8113
Diego L CostaImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-9440-2814
Sivaranjani NamasivayamImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Nicolas RiteauImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Olena KamenyevaResearch Technology Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.ORCID 0000-0002-6541-5616
Lara MitterederImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
Katrin D Mayer-BarberInflammation and Innate Immunity Unit, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health Bethesda, MD.
Bruno B AndradeInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil.ORCID 0000-0001-6833-3811
Alan SherImmunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD asher@nih.gov.ORCID 0000-0001-7053-2895
National Institutes of Health · USEscola Bahiana de Medicina e Saúde Pública · BRUniversité d'Orléans · FR

Funding

Innate inflammatory responses during pulmonary infectionsZIAAI001207 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI MAYER-BARBER, KATRIN · 2015 to 2025
$13.6M
Regulation Of Immunopathology In Bacterial And Parasitic DiseaseZIAAI000843 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI SHER, ALAN · 2009 to 2022
$11.1M
6 · The paper itself

Abstract

Necrotic cell death during

Indexed as

AnimalsCell DeathCells, CulturedFerroptosisGlutathioneHost-Pathogen InteractionsHumansIronIron Chelating AgentsLipid PeroxidationMacrophagesMaleMice, Inbred C57BLMycobacterium tuberculosisPhospholipid Hydroperoxide Glutathione PeroxidaseTuberculosisGlutathioneglutathione peroxidase 4, mouseIronIron Chelating AgentsPhospholipid Hydroperoxide Glutathione Peroxidase

Identifiers

PMID30787033
PMCPMC6400546
OpenAlexW2916265250

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.