Evidence map›Paper›PMID 30787021›Full record

ArticleBlood advances2019

ELMO1 deficiency enhances platelet function.

Akruti Patel, John Kostyak, Carol Dangelmaier, Rachit Badolia, Dheeraj Bhavanasi, Joseph E Aslan, Salim Merali, Soochong Kim, Johannes A Eble, Lawrence Goldfinger and 1 more

Open access · goldAbstract read
In one paragraph

Article in Blood advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  3. Review
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  9. Article
  10. Functional Verification of NovelFrontiers in cell and developmental biology · 2021
    Article
  11. PI3K inhibitors in thrombosis and cardiovascular disease.Clinical and translational medicine · 2020
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Akruti PatelDepartment of Physiology and.
John KostyakDepartment of Physiology and.
Carol DangelmaierDepartment of Physiology and.
Rachit BadoliaDepartment of Physiology and.
Dheeraj BhavanasiDepartment of Physiology and.
Joseph E AslanKnight Cardiovascular Institute, School of Medicine, Oregon Health & Science University, Portland, OR.ORCID 0000-0002-8873-0387
Salim MeraliDepartment of Pharmacology, Temple University School of Medicine, Philadelphia, PA.
Soochong KimDepartment of Physiology and.
Johannes A EbleInstitute of Physiological Chemistry and Pathobiochemistry, University of Münster, Münster, Germany; and.
Lawrence GoldfingerSol Sherry Thrombosis Research Center, Temple University School of Medicine, Philadelphia, PA.
Satya KunapuliDepartment of Physiology and.
Temple University · USOregon Health & Science University · USUniversity of Münster · DE

Funding

Functional PKC Isoforms in PlateletsR01HL093231 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KUNAPULI, SATYA P. · 2009 to 2017
$3.6M
Novel small G protein pathway regulators of GPVI signaling in plateletsR01HL137207 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI GOLDFINGER, LAWRENCE E, KUNAPULI, SATYA P. · 2017 to 2020
$2.5M
Novel regulation of CLEC-2 signaling in PlateletsR01HL132171 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KUNAPULI, SATYA P. · 2017 to 2020
$1.8M
Novel functional protein tyrosine phosphatases in plateletsR01HL137721 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KUNAPULI, SATYA P. · 2018 to 2020
$1.6M
NHLBI NIH HHS R01 HL093231NHLBI NIH HHS R01 HL132171NHLBI NIH HHS R01 HL137207NHLBI NIH HHS R01 HL137721
6 · The paper itself

Abstract

Phosphatidylinositol 3-kinase is an important signaling molecule that, once activated, leads to the generation of phosphatidylinositol (3,4,5)-trisphosphate (PIP

Indexed as

Platelet AggregationAdaptor Proteins, Signal TransducingAnimalsBlood PlateletsGene DeletionHemostasisHumansMicePlatelet Glycoprotein GPIIb-IIIa ComplexThrombosisThromboxanesAdaptor Proteins, Signal TransducingELMO1 protein, mousePlatelet Glycoprotein GPIIb-IIIa ComplexThromboxanes

Identifiers

PMID30787021
PMCPMC6391667
OpenAlexW2918057145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.