ArticleSubstance abuse treatment, prevention, and policy2019
Drug-induced prolonged corrected QT interval in patients with methadone and opium overdose.
Article in Substance abuse treatment, prevention, and policy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- The effects of opium on the cardiovascular system: a review of side effects, uses, and potential mechanisms.Substance abuse treatment, prevention, and policy · 2020Pooled it
- Enhancing Hepatitis B and C Prevention Among People Who Use Drugs: Evaluating an Educational Intervention at a Drop-In Center in Southwest Iran based on Protection Motivation Theory.BMC public health · 2025Trial
- Research progress on the relationship between long QT syndrome (LQTS) and epilepsy: A review.Medicine · 2026Review
- Key Indicators of Performance-Based Payment to Physicians by Insurance Organizations in Iran.Medical journal of the Islamic Republic of Iran · 2026Article
- Quality of Sleep and Related Factors in Individuals Undergoing Methadone Maintenance Treatment.Addiction & health · 2025Article
- Sociodemographic and Toxico-clinical Characteristics of Patients with Opioid/Stimulant Poisoning.Addiction & health · 2025Article
- Associations of Opium Use with Metabolic Syndrome in Fasa PERSIAN Cohort Study: A Population-Based Study.International journal of preventive medicine · 2025Article
- Opioids-Induced Long QT Syndrome: A Challenge to Cardiac Health.Cardiovascular toxicology · 2024Review
- Epidemiology of substance and opium use among adult residents of Tehran; a comprehensive report from Tehran cohort study (TeCS).BMC psychiatry · 2024Article
- Opioid Use Disorder and intracerebral hemorrhage in Isfahan, Iran: a case-control study.Frontiers in neurology · 2024Article
- A comparative study of religious beliefs, spiritual intelligence and spiritual well-being in two therapies based on education (anonymous drug user) and methadone in drug user in Iran.BMC research notes · 2023Article
- The Effect of Healthy Mental Lifestyle Package On Sleep Quality, Mental Health, and Lifestyle of Substance Users.Advanced biomedical research · 2023Article
- Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2021Article
- Prevalence of drug use, alcohol consumption, cigarette smoking and measure of socioeconomic-related inequalities of drug use among Iranian people: findings from a national survey.Substance abuse treatment, prevention, and policy · 2020Article
- The Effect of Transcranial Direct Current Stimulation on Relapse, Anxiety, and Depression in Patients With Opioid Dependence Under Methadone Maintenance Treatment: A Pilot Study.Frontiers in pharmacology · 2020Article
- Cardiovascular Complications Following Acute Methadone Poisoning in Patients with and Without a History of Long-term Methadone Use.Journal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIran is a country with the highest rate of opioid addiction in the world. The most commonly used opioid in Iran is opium, and methadone is in second place. The trend of drug use has changed from opium to methadone from 2006 to 2011. Presence of a large number of addicted people and methadone maintenance therapy clinics make methadone readily available in Iran. Therefore, evaluation of the epidemiological characteristic of methadone toxicity and its effects on the heart is essential.
methodsIn This cross-sectional, retrospective, descriptive, analytical study all patients with methadone or opium toxicity who had been admitted to Vasei hospital, Sabzevar, Iran, during the years 2015 and 2016 were included, and their records were evaluated. Demographic data, addiction history, underlying diseases, and the outcome of admission were recorded. Then, corrected QT interval (QTc) of the first ECG of the patients after admission was evaluated.
resultsThe Majority of toxicities occurred in those above 30 years of age (71.4%), who lived in cities (62.8%), and were married (69.2%). A positive history of addiction was considerably higher in the opium group (72.3% versus 43.3%). There was no significant difference regarding QTc prolongation between patients with methadone and opium toxicity (p = 0.3).
conclusionQTc prolongation is one of the adverse effects of methadone or opium overdose. It seems that significant QTc prolongation is not uncommon among patients with opium overdose.
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