Evidence map›Paper›PMID 30786871›Full record

ArticleBMC ophthalmology2019

Modeling and simulation of phototransduction cascade in vertebrate rod photoreceptors.

Guofeng Pan, Jinglu Tan, Ya Guo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Guofeng PanMinistry of Education, Key Laboratory of Advanced Process Control for Light Industry, Jiangnan University, Wuxi, 214122, China.
Jinglu TanUniversity of Missouri, Columbia, MO, 65211, USA.
Ya GuoMinistry of Education, Key Laboratory of Advanced Process Control for Light Industry, Jiangnan University, Wuxi, 214122, China. guoy@missouri.edu.

Funding

National Natural Science Foundation of China 31771680
6 · The paper itself

Abstract

backgroundThe activation of phototransduction cascade in rod photoreceptors has been well studied in literature, but there is a lack of a mature kinetic model structure covering both the activation and inactivation processes.

methodsIn this work, a kinetic model structure is developed to describe the major activation and inactivation processes in vertebrate rod photoreceptors with the electroretinogram (ERG) as output. Simulation was performed to validate developed model structure.

resultsThe developed model structure could fit experimental data with small error.

conclusionsThe result indicated that the developed model structure could show the inactivation process of phototransduction cascades in the rod photoreceptors.

Indexed as

AnimalsElectroretinographyLight Signal TransductionMiceModels, AnimalModels, BiologicalRetinal Rod Photoreceptor CellsERG a waveKinetic model structurePhotoreceptorPhototransductionRod

Identifiers

PMID30786871
PMCPMC6381673

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.