Evidence map›Paper›PMID 30786858›Full record

ArticleBMC microbiology2019

Genome plasticity favours double chromosomal Tn4401b-bla

Deisy Abril, Ricaurte Alejandro Marquez-Ortiz, Betsy Castro-Cardozo, José Ignacio Moncayo-Ortiz, Narda María Olarte Escobar, Zayda Lorena Corredor Rozo, Niradiz Reyes, Catalina Tovar, Héctor Fabio Sánchez, Jaime Castellanos and 4 more

Abstract read
In one paragraph

Article in BMC microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed.

  1. ISAntimicrobial agents and chemotherapy · 2026
    Article
  2. Role of Mobilome in Carbapenem Resistance.Antibiotics (Basel, Switzerland) · 2026
    Review
  3. Unveiling a new sequence type in high-risk clonal complexes of virulent carbapenem-resistant Pseudomonas aeruginosa carrying blaBrazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  4. TnCurrent research in microbial sciences · 2026
    Article
  5. New Insights inAntibiotics (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2025
    Review
  8. High-riskHeliyon · 2025
    Article
  9. Article
  10. Characterization of genetic context ofFrontiers in microbiology · 2025
    Article
  11. Global genomic epidemiology and plasmid-mediated dissemination ofCurrent research in microbial sciences · 2025
    Article
  12. Review
  13. Article
  14. Worldwide Dissemination ofAntibiotics (Basel, Switzerland) · 2023
    Review
  15. Dissemination of Metallo-β-Lactamase-ProducingInternational journal of molecular sciences · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Genetic Diversity of Multidrug-ResistantFrontiers in microbiology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Deisy AbrilBacterial Molecular Genetics Laboratory, Universidad El Bosque, Carrera 9 N°131A-02, Bogotá D.C, Colombia.
Ricaurte Alejandro Marquez-OrtizBacterial Molecular Genetics Laboratory, Universidad El Bosque, Carrera 9 N°131A-02, Bogotá D.C, Colombia.
Betsy Castro-CardozoBacterial Molecular Genetics Laboratory, Universidad El Bosque, Carrera 9 N°131A-02, Bogotá D.C, Colombia.
José Ignacio Moncayo-OrtizGrupo de Investigación en Enfermedades Infecciosas- GRIENI, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira, Colombia.
Narda María Olarte EscobarHospital El Tunal E.S.E, Bogotá D.C, Colombia.
Zayda Lorena Corredor RozoBacterial Molecular Genetics Laboratory, Universidad El Bosque, Carrera 9 N°131A-02, Bogotá D.C, Colombia.
Niradiz ReyesGrupo de Genética y Biología Molecular, Universidad de Cartagena, Cartagena, Colombia.
Catalina TovarGrupo de Investigación en Enfermedades Tropicales y Resistencia Bacteriana, Universidad del Sinú, Montería, Colombia.
Héctor Fabio SánchezHospital Universitario Departamental de Nariño, Pasto, Colombia.
Jaime CastellanosGrupo de Patogénesis Infecciosa, Universidad Nacional de Colombia, Bogotá D.C, Colombia.
Yina Marcela Guaca-GonzálezGrupo de Investigación en Enfermedades Infecciosas- GRIENI, Facultad de Ciencias de la Salud, Universidad Tecnológica de Pereira, Pereira, Colombia.
Carmen Elisa Llanos-UribeESE-Hospital Universitario San Jorge, Pereira, Colombia.
Natasha Vanegas GómezBacterial Molecular Genetics Laboratory, Universidad El Bosque, Carrera 9 N°131A-02, Bogotá D.C, Colombia.
Javier Escobar-PérezBacterial Molecular Genetics Laboratory, Universidad El Bosque, Carrera 9 N°131A-02, Bogotá D.C, Colombia. escobarjavier@unbosque.edu.co.ORCID 0000-0002-0432-6978

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPseudomonas aeruginosa Sequence Type 235 is a clone that possesses an extraordinary ability to acquire mobile genetic elements and has been associated with the spread of resistance genes, including genes that encode for carbapenemases. Here, we aim to characterize the genetic platforms involved in resistance dissemination in bla

resultsIn a prospective surveillance study of infections in adult patients attended in five ICUs in five distant cities in Colombia, 58 isolates of P. aeruginosa were recovered, of which, 27 (46.6%) were resistant to carbapenems. The molecular analysis showed that 6 (22.2%) and 4 (14.8%) isolates harboured the bla

conclusionThis is the first report of a double Tn4401b chromosomal insertion in P. aeruginosa, just within a new genomic island (PAGI-17). This finding indicates once again the great genomic plasticity of this microorganism.

Indexed as

Chromosomes, BacterialDNA Transposable ElementsGenome, BacterialGenomic IslandsAnti-Bacterial AgentsBacterial ProteinsBacterial Typing Techniquesbeta-LactamasesCarbapenemsColombiaDNA, BacterialDrug Resistance, Multiple, BacterialHumansIntensive Care UnitsMicrobial Sensitivity TestsMultilocus Sequence TypingAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsDNA, BacterialDNA Transposable Elementsbla KPC-2CarbapenemsColombiaPseudomonas aeruginosaResistanceST235

Identifiers

PMID30786858
PMCPMC6381643

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.