Evidence map›Paper›PMID 30786815›Full record

ArticleCancer biology & therapy2019

Activation of CD3

Li-Jun Xue, Xiao-Bei Mao, Xiao-Bei Liu, Han Gao, Ya-Nan Chen, Ting-Ting Dai, Sheng-Wen Shao, Hong-Min Chen, Xiao-Yuan Chu

Open access · bronzeAbstract read
In one paragraph

Article in Cancer biology & therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Developing a potent vaccine againstExpert reviews in molecular medicine · 2024
    Review
  5. Review
  6. Review
  7. Article
  8. Pivotal role ofFrontiers in medicine · 2024
    Review
  9. Effects and mechanisms ofFrontiers in immunology · 2024
    Review
  10. Article
  11. Review
  12. Effects ofFrontiers in immunology · 2022
    Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Li-Jun Xuea Department of Oncology , Jinling Hospital, Nanjing University Clinical School of Medicine , Nanjing , China.ORCID 0000-0003-4510-528X
Xiao-Bei Maoa Department of Oncology , Jinling Hospital, Nanjing University Clinical School of Medicine , Nanjing , China.
Xiao-Bei Liua Department of Oncology , Jinling Hospital, Nanjing University Clinical School of Medicine , Nanjing , China.
Han Gaoc Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences , Chinese Academy of Science , Shanghai , China.
Ya-Nan Chena Department of Oncology , Jinling Hospital, Nanjing University Clinical School of Medicine , Nanjing , China.
Ting-Ting Daia Department of Oncology , Jinling Hospital, Nanjing University Clinical School of Medicine , Nanjing , China.
Sheng-Wen Shaod Laboratory of Innovation , Medical School of Huzhou Teachers College , Huzhou , China.
Hong-Min Chenb State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health , Xiamen University , Xiamen , China.
Xiao-Yuan Chua Department of Oncology , Jinling Hospital, Nanjing University Clinical School of Medicine , Nanjing , China.
Nanjing General Hospital of Nanjing Military Command · CNXiamen University · CNHuzhou University · CNShanghai Institutes for Biological Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most of gastric carcinoma (GC) is attributed to infection by Helicobacter pylori (H. pylori) but there is increasing evidence that the positive H. pylori status correlates with better prognosis in GC. The H. pylori-induced cellular immune response may suppress cancer and in this work, recombinant pcDNA3 plasmids encoding various fragments of H. pylori virulence genes of cagA, vacA and babA are constructed and combined into groups to immunize BALB/c mice. The activated splenic CD3

Indexed as

AnimalsApoptosisBacterial ProteinsBacterial VaccinesHelicobacter InfectionsHelicobacter pyloriHost-Pathogen InteractionsHumansImmunotherapyLymphocyte ActivationLymphocytes, Tumor-InfiltratingMiceStomach NeoplasmsT-Lymphocyte SubsetsVaccines, DNABacterial ProteinsBacterial VaccinesVaccines, DNAadoptive transfusionDNA vaccineGastric carcinomaimmune responseimmunotherapyprognosis

Identifiers

PMID30786815
PMCPMC6605983
OpenAlexW2915373952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.