ArticleInvestigative ophthalmology & visual science2019
Age-Related Alterations in Retinal Tissue Perfusion and Volumetric Vessel Density.
Article in Investigative ophthalmology & visual science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 2 syntheses or guidelines pooled it, 92 citations in OpenAlex.
- Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis.Journal of neuroinflammation · 2023Pooled it
- The Application of Optical Coherence Tomography Angiography in Systemic Hypertension: A Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Retinal Neurovascular and Mitochondrial Function Signatures in Response to a 24-Week Yoga Intervention in Healthy Adults.Investigative ophthalmology & visual science · 2025Trial
- Decreased retinal capillary density as a beneficial response to 24-week high-speed circuit resistant training in healthy older adults.Microvascular research · 2024Trial
- Detailed Analysis of Intraretinal Layers and Their Correlation to Brain Structures in Normal Healthy Aging.Translational vision science & technology · 2026Article
- Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Chain Concentrations Are Inversely Associated with Retinal Microvascular Perfusion and Vessel Density in Cognitively Normal Individuals with Familial or Genetic Risk Factors for Alzheimer's Disease.Diagnostics (Basel, Switzerland) · 2026Article
- Independent Conjunctival and Retinal Microcirculatory Improvements Following OcufolinCurrent eye research · 2026Article
- Retinal neurovascular and mitochondrial function signatures related to cognition improvement following yoga exercise in older adults.PloS one · 2026Article
- Retinal Vasculature in Schizophrenia Spectrum Disorder.Bioengineering (Basel, Switzerland) · 2025Article
- Associations Between Retinal Microvasculature, Orbital Blood Flow, and Cerebral Blood Flow in Healthy Adults.Investigative ophthalmology & visual science · 2025Article
- Characterizing Retinal Mitochondrial Function and Its Relations to Intraretinal Thicknesses in Healthy Adults.Current eye research · 2025Article
- Progressive Retinal Vascular and Neuronal Degeneration in BXD32 Mice: A Model for Age-Dependent Neurovascular Pathology.International journal of molecular sciences · 2025Article
- Retinal Neurovascular Signatures in Parkinson's Disease.Investigative ophthalmology & visual science · 2025Article
- Article
- Aging affects retinal oxygen and blood flow metrics in mice.Experimental eye research · 2025Article
- Early Renal Dysfunction and Reduced Retinal Vascular Density Assessed by Angio-OCT in Hypertensive Patients.Biomedicines · 2025Article
- Quantitative Analysis of Early Retinal Changes and OCT Parameters in Diabetic Subjects with and Without Retinopathy.Diagnostics (Basel, Switzerland) · 2025Article
- Choroidopathy in patients with systemic lupus erythematosus using enhanced depth imaging spectral domain optical coherence tomography and optical coherence tomography angiography.International journal of ophthalmology · 2025Article
- A Novel Foundation Model-Based Framework for Multimodal Retinal Age Prediction.IEEE journal of translational engineering in health and medicine · 2025Article
- Serum Apolipoprotein B and B/A1 Ratio as Early Negative Biomarkers for OCT- and OCTA-Detected Retinal Changes in Diabetic Macular Edema.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Purpose: To determine age-related alterations in the retinal tissue perfusion (RTP) and volumetric vessel density (VVD) in healthy subjects. Methods: Total 148 healthy subjects (age 18 to 83 years) were enrolled and divided into four groups (G1, <35 years; G2, 35 ∼ 49 years; G3, 50 ∼ 64 years; and G4, ≥65 years). The RTP and VVD were measured at the macula. The RTP was calculated as the blood flow supplying the macular area (ϕ 2.5 mm) divided by the perfused tissue volume of the inner retina from the inner limiting membrane to the outer plexiform layer. The VVD of the macula (ϕ 2.5 mm) was calculated as the vessel density divided by the corresponding tissue volume. Results: The RTP and VVD of the retinal vascular network and deep vascular plexus (DVP) reached a peak in G2. Compared to G2, G4 had significantly lower RTP and VVD of DVP (P < 0.05). After 35 years old, age was negatively related to the RTP (r = -0.26, P = 0.02) and VVD of the DVP (r = -0.47, P < 0.001). However, age was positively related to VVD of the superficial vascular plexus (SVP; r = 0.24, P = 0.04) in subjects aged more than 35 years. The RTP was correlated to VVD measurements (r = 0.23-0.37, P < 0.01). Conclusions: This is the first study to reveal the age-related alterations in the RTP and VVD during normal aging in a healthy population. Decreased RTP and VVD in the DVP along with increased VVD in the SVP may represent a characteristic pattern of normal aging in the healthy population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.