Evidence map›Paper›PMID 30786138›Full record

SynthesisBJOG : an international journal of obstetrics and gynaecology2019

Impact of maternal body mass index and gestational weight gain on pregnancy complications: an individual participant data meta-analysis of European, North American and Australian cohorts.

S Santos, E Voerman, P Amiano, H Barros, L J Beilin, A Bergström, M-A Charles, L Chatzi, C Chevrier, G P Chrousos and 77 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BJOG : an international journal of obstetrics and gynaecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 344 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
344citing papers in PubMed, 11 pooled it
48.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

344 citing papers in PubMed, 11 syntheses or guidelines pooled it, 574 citations in OpenAlex.

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  14. Can maternal metformin protect the developing fetal brain?American journal of obstetrics and gynecology · 2026
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284 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

87 authors at 20 institutions in 18 countries.

S SantosThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
E VoermanThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
P AmianoPublic Health Division of Gipuzkoa, San Sebastián, Spain.
H BarrosEPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
L J BeilinMedical School, Royal Perth Hospital Unit, The University of Western Australia, Perth, WA, Australia.
A BergströmInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
M-A CharlesINSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), ORCHAD Team, Villejuif, France.
L ChatziDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
C ChevrierInserm UMR 1085, Irset - Research Institute for Environmental and Occupational Health, Rennes, France.
G P ChrousosFirst Department of Pediatrics, Athens University Medical School, 'Aghia Sophia' Children's Hospital, National and Kapodistrian University of Athens, Athens, Greece.
E CorpeleijnDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
O CostaEpidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.
N CostetInserm UMR 1085, Irset - Research Institute for Environmental and Occupational Health, Rennes, France.
S CrozierMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
G DevereuxLiverpool School of Tropical Medicine, Liverpool, UK.
M DoyonCentre de Recherche du Centre Hospitalier de l'Universite de Sherbrooke, Sherbrooke, QC, Canada.
M EggesbøDepartment of Exposure and Environmental Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.
M P FantiniThe Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
S FarchiDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
F ForastiereDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
V GeorgiuFaculty of Medicine, Department of Social Medicine, University of Crete, Heraklion, Greece.
K M GodfreyMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
D GoriThe Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
V GroteDivision of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilian-Universität Munich, Munich, Germany.
W HankeDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
I Hertz-PicciottoDepartment of Public Health Sciences, School of Medicine, University of California Davis, Davis, CA, USA.
B HeudeINSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), ORCHAD Team, Villejuif, France.
M-F HivertCentre de Recherche du Centre Hospitalier de l'Universite de Sherbrooke, Sherbrooke, QC, Canada.
D HryhorczukCenter for Global Health, University of Illinois College of Medicine, Chicago, IL, USA.
R-C HuangTelethon Kids Institute, The University of Western Australia, Perth, WA, Australia.
H InskipMRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK.
A M KarvonenDepartment of Health Security, National Institute for Health and Welfare, Kuopio, Finland.
L C KennyIrish Centre for Fetal and Neonatal Translational Research, Cork University Maternity Hospital, University College Cork, Cork, Ireland.
B KoletzkoDivision of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, Ludwig-Maximilian-Universität Munich, Munich, Germany.
L K KüpersDepartment of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
H LagströmDepartment of Public Health, University of Turku, Turku, Finland.
I LehmannDepartment of Environmental Immunology/Core Facility Studies, Helmholtz Centre for Environmental Research - UFZ, Leipzig, Germany.
P MagnusDivision of Health Data and Digitalization, Norwegian Institute of Public Health, Oslo, Norway.
R MajewskaDepartment of Epidemiology, Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Krakow, Poland.
J MäkeläTurku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland.
Y ManiosDepartment of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece.
F M McAuliffeUCD Perinatal Research Centre, Obstetrics& Gynaecology, School of Medicine, National Maternity Hospital, University College Dublin, Dublin, Ireland.
S W McDonaldDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
J MeheganUCD Perinatal Research Centre, School of Public Health and Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland.
E MelénInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
M MommersDepartment of Epidemiology, Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands.
C S MorgenNational Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.
G MoschonisDepartment of Rehabilitation, Nutrition and Sport, La Trobe University, Melbourne, Vic, Australia.
D MurrayIrish Centre for Fetal and Neonatal Translational Research, Cork University Maternity Hospital, University College Cork, Cork, Ireland.
C Ní ChaoimhIrish Centre for Fetal and Neonatal Translational Research, Cork University Maternity Hospital, University College Cork, Cork, Ireland.
E A NohrResearch Unit for Gynaecology and Obstetrics, Institute for Clinical Research, University of Southern Denmark, Odense, Denmark.
A-M Nybo AndersenDepartment of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark.
E OkenDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
Ajjm OostvogelsDepartment of Public Health, Amsterdam Public Health Research Institute, Academic Medical Center, Amsterdam, the Netherlands.
A PacDepartment of Epidemiology, Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College, Krakow, Poland.
E PapadopoulouDepartment of Environmental Exposures and Epidemiology, Domain of Infection Control and Environmental Health, Norwegian Institute of Public Health, Oslo, Norway.
J PekkanenDepartment of Health Security, National Institute for Health and Welfare, Kuopio, Finland.
C PizziDepartment of Medical Sciences, University of Turin, Turin, Italy.
K PolanskaDepartment of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
D PortaDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
L RichiardiDepartment of Medical Sciences, University of Turin, Turin, Italy.
S L Rifas-ShimanDepartment of Population Medicine, Harvard Medical School, Harvard Pilgrim Health Care Institute, Boston, MA, USA.
N RoeleveldDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
L RonfaniInstitute for Maternal and Child Health - IRCCS 'Burlo Garofolo', Trieste, Italy.
A C SantosEPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
M StandlInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
H StigumDepartment of Non-communicable Diseases, Norwegian Institute of Public Health, Oslo, Norway.
C StoltenbergNorwegian Institute of Public Health, Oslo, Norway.
E ThieringInstitute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
C ThijsDepartment of Epidemiology, Care and Public Health Research Institute, Maastricht University, Maastricht, the Netherlands.
M TorrentIb-salut, Area de Salut de Menorca, Menorca, Spain.
S C ToughDepartment of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
T TrnovecDepartment of Environmental Medicine, Slovak Medical University, Bratislava, Slovak Republic.
S TurnerChild Health, Royal Aberdeen Children's Hospital, Aberdeen, UK.
Mmhj van GelderDepartment for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
L van RossemJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
A von BergDepartment of Pediatrics, Research Institute, Marien-Hospital Wesel, Wesel, Germany.
M VrijheidCIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
Tgm VrijkotteDepartment of Public Health, Amsterdam Public Health Research Institute, Academic Medical Center, Amsterdam, the Netherlands.
J WestBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
A H WijgaNational Institute for Public Health and the Environment, Bilthoven, the Netherlands.
J WrightBradford Institute for Health Research, Bradford Royal Infirmary, Bradford, UK.
O ZvinchukDepartment of Medical and Social Problems of Family Health, Institute of Pediatrics, Obstetrics and Gynecology, Kyiv, Ukraine.
Tia SørensenDepartment of Public Health, Section of Epidemiology, University of Copenhagen, Copenhagen, Denmark.
D A LawlorMRC Integrative Epidemiology Unit, Oakfield House, Oakfield Grove, University of Bristol, Bristol, UK.
R GaillardThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Vwv JaddoeThe Generation R Study Group, Erasmus MC, University Medical Center, Rotterdam, the Netherlands.
Erasmus MC · NLNorwegian Institute of Public Health · NOInserm · FRLudwig-Maximilians-Universität München · DEBradford Royal Infirmary · GBCork University Hospital · IEHarvard Pilgrim Health Care · USJagiellonian University · PLMaastricht University · NLMRC Epidemiology Unit · GBNofer Institute of Occupational Medicine · PLRadboud University Medical Center · NLUniversity of Bologna · ITUniversity of Calgary · CAUniversity of Copenhagen · DKUniversity of Turin · ITUniversity of Western Australia · AUAcademic Medical Center · NLBiogipuzkoa Health Research Institute · ESCentre Hospitalier Universitaire de Sherbrooke · CA

Funding

Prenatal environmental determinants of health in young adulthood: a lifecourse approachR01HD034568 · NICHD · HARVARD PILGRIM HEALTH CARE, INC. · PI Marie-France Hivert, Emily Oken · 1998 to 2026
$20.6M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUH3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI OKEN, EMILY · 2018 to 2022
$11.7M
Translational Research Core - Health Engagement & Action Translational (HEAT)P30DK092924 · NIDDK · KAISER FOUNDATION RESEARCH INSTITUTE · PI Alyce Sophia Adams, HILARY Kessler SELIGMAN · 2011 to 2026
$9.2M
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methodsUG3OD023286 · OD · HARVARD PILGRIM HEALTH CARE, INC. · PI KLEINMAN, KENNETH P., OKEN, EMILY · 2016 to 2017
$4.1M
British Heart Foundation PG/14/33/30827British Heart Foundation RG/15/17/31749Medical Research Council G0601712Medical Research Council MC_UP_A620_1017Medical Research Council MC_UU_00011/6Medical Research Council MC_UU_12011/4Medical Research Council MC_UU_12013/5Medical Research Council MR/K006665/1Medical Research Council MR/K021656/1NICHD NIH HHS R01 HD034568NIDDK NIH HHS P30 DK092924NIH HHS UG3 OD023286NIH HHS UH3 OD023286
6 · The paper itself

Abstract

objectiveTo assess the separate and combined associations of maternal pre-pregnancy body mass index (BMI) and gestational weight gain with the risks of pregnancy complications and their population impact.

designIndividual participant data meta-analysis of 39 cohorts.

settingEurope, North America, and Oceania. POPULATION: 265 270 births.

methodsInformation on maternal pre-pregnancy BMI, gestational weight gain, and pregnancy complications was obtained. Multilevel binary logistic regression models were used.

main outcome measuresGestational hypertension, pre-eclampsia, gestational diabetes, preterm birth, small and large for gestational age at birth.

resultsHigher maternal pre-pregnancy BMI and gestational weight gain were, across their full ranges, associated with higher risks of gestational hypertensive disorders, gestational diabetes, and large for gestational age at birth. Preterm birth risk was higher at lower and higher BMI and weight gain. Compared with normal weight mothers with medium gestational weight gain, obese mothers with high gestational weight gain had the highest risk of any pregnancy complication (odds ratio 2.51, 95% CI 2.31- 2.74). We estimated that 23.9% of any pregnancy complication was attributable to maternal overweight/obesity and 31.6% of large for gestational age infants was attributable to excessive gestational weight gain.

conclusionsMaternal pre-pregnancy BMI and gestational weight gain are, across their full ranges, associated with risks of pregnancy complications. Obese mothers with high gestational weight gain are at the highest risk of pregnancy complications. Promoting a healthy pre-pregnancy BMI and gestational weight gain may reduce the burden of pregnancy complications and ultimately the risk of maternal and neonatal morbidity. TWEETABLE ABSTRACT: Promoting a healthy body mass index and gestational weight gain might reduce the population burden of pregnancy complications.

Indexed as

Body Mass IndexAdultAustraliaBirth WeightCohort StudiesEuropeFemaleGestational AgeGestational Weight GainHumansInfant, NewbornNorth AmericaOdds RatioOverweightPregnancyPregnancy ComplicationsBirthweightbody mass indexpregnancy complicationspreterm birthweight gain

Identifiers

PMID30786138
PMCPMC6554069
OpenAlexW2916077285

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.