ArticleAnnals of neurology2019
Smoking and amyotrophic lateral sclerosis: A mendelian randomization study.
Article in Annals of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed.
- Identifying Modifiable Factors and Their Joint Effect on Amyotrophic Lateral Sclerosis: A Prospective Cohort Study in the UK Biobank.Brain and behavior · 2026Article
- Analysis of retinal markers and incident amyotrophic lateral sclerosis: An optical coherence tomography-based cohort study.PLoS medicine · 2025Article
- Clinical and Sociodemographic Factors Related to Amyotrophic Lateral Sclerosis in Spain: A Pilot Study.Journal of clinical medicine · 2024Article
- Lifestyle and medical conditions in relation to ALS risk and progression-an introduction to the Swedish ALSrisc Study.Journal of neurology · 2024Article
- Tuberculin responses after BCG vaccination predict amyotrophic lateral sclerosis risk.Brain, behavior, & immunity - health · 2023Article
- Evaluating the causal effect of tobacco smoking on white matter brain aging: a two-sample Mendelian randomization analysis in UK Biobank.Addiction (Abingdon, England) · 2023Article
- The influence of environmental risk factors in the development of ALS in the Mediterranean Island of Cyprus.Frontiers in neurology · 2023Article
- Environmental risk factors in multiple sclerosis: bridging Mendelian randomization and observational studies.Journal of neurology · 2022Review
- A review of Mendelian randomization in amyotrophic lateral sclerosis.Brain : a journal of neurology · 2022Review
- Review
- Higher blood high density lipoprotein and apolipoprotein A1 levels are associated with reduced risk of developing amyotrophic lateral sclerosis.Journal of neurology, neurosurgery, and psychiatry · 2022Article
- Application of a bioinformatic pipeline to RNA-seq data identifies novel virus-like sequence in human blood.G3 (Bethesda, Md.) · 2021Article
- Oxidative Stress as a Therapeutic Target in Amyotrophic Lateral Sclerosis: Opportunities and Limitations.Diagnostics (Basel, Switzerland) · 2021Review
- Serum Creatinine Protects Against Amyotrophic Lateral Sclerosis: a Mendelian Randomization Study.Molecular neurobiology · 2021Article
- Diagnostics of Amyotrophic Lateral Sclerosis: Up to Date.Diagnostics (Basel, Switzerland) · 2021Review
- Pre-Morbid Risk Factors for Amyotrophic Lateral Sclerosis: Prospective Cohort Study.Clinical epidemiology · 2021Article
- No association of GSTP1 rs1695 polymorphism with amyotrophic lateral sclerosis: A case-control study in the Brazilian population.PloS one · 2021Article
- A Novel Method for Mendelian Randomization Analyses With Pleiotropy and Linkage Disequilibrium in Genetic Variants From Individual Data.Frontiers in genetics · 2021Article
- Causal Association of Leukocytes Count and Amyotrophic Lateral Sclerosis: a Mendelian Randomization Study.Molecular neurobiology · 2020Article
- Smoking and multiple sclerosis risk: a Mendelian randomization study.Journal of neurology · 2020Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we examined the potential causal effect of smoking on amyotrophic lateral sclerosis (ALS) using the Project MinE data involving 12,577 patients with ALS and 23,475 controls in a Mendelian randomization (MR) framework. The MR approach has the potential to investigate a causal relationship between a risk factor and a disease, avoiding confounding and information bias that often present in conventional epidemiological studies. We found that smokers had a higher risk of ALS compared to never smokers. Our study thus provides evidence for a causal relationship between smoking and ALS. Ann Neurol 2019;85:482-484.
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