ArticleActa cirurgica brasileira2019
Bone callus formation is highly disrupted by dietary restriction in growing rats sustaining a femoral fracture1.
Article in Acta cirurgica brasileira, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Preoperative malnutrition is associated with increased postoperative complications following lumbar fusion: a propensity-matched analysis.Journal of spine surgery (Hong Kong) · 2026Article
- Recent Advances in Bone Tissue Engineering: Enhancing the Potential of Mesenchymal Stem Cells for Regenerative Therapies.Current issues in molecular biology · 2025Review
- Caloric restriction reduces trabecular bone loss during aging and improves bone marrow adipocyte endocrine function in male mice.Frontiers in endocrinology · 2024Article
- Refeeding partially reverses impaired fracture callus in undernourished rats.Frontiers in endocrinology · 2024Article
- Evaluating the beneficial effects of dietary restrictions: A framework for precision nutrigeroscience.Cell metabolism · 2021Review
- Advances in Growth Factor Delivery for Bone Tissue Engineering.International journal of molecular sciences · 2021Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the effects of food restriction on fracture healing in growing rats.
methodsSixty-eight male Wistar rats were assigned to two groups: (1) Control and (2) Dietary restriction. After weaning the dietary restricted animals were fed ad libitum for 42 days with 50% of the standard chow ingested by the control group. Subsequently, the animals underwent bone fracture at the diaphysis of the right femur, followed by surgical stabilization of bone fragments. On days 14 and 28 post-fracture, the rats were euthanized, and the fractured femurs were dissected, the callus was analyzed by dual-energy X-ray absorptiometry, micro-computed tomography, histomorphometry, mechanical tests, and gene expression.
resultsDietary restriction decreased body mass gain and resulted in several phenotypic changes at the bone callus (a delay in cell proliferation and differentiation, lower rate of newly formed bone and collagen deposition, reductions in bone callus density and size, decrease in tridimensional callus volume, deterioration in microstructure, and reduction in bone callus strength), together with the downregulated expression of osteoblast-related genes.
conclusionDietary restriction had detrimental effects on osseous healing, with a healing delay and a lower quality of bone callus formation.
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