Evidence map›Paper›PMID 30785353›Full record

ArticleAmerican journal of physiology. Renal physiology2019

IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis.

Rebecca S Zee, Evaristus C Mbanefo, Loc H Le, Luke F Pennington, Justin I Odegaard, Theodore S Jardetzky, Abdulaziz Alouffi, Jude Akinwale, Franco H Falcone, Michael H Hsieh

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Renal physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.2field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Schistosome immunomodulators.PLoS pathogens · 2021
    Review
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  4. Article
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Rebecca S ZeeDivision of Urology, Children's National Medical Center , Washington, District of Columbia.
Evaristus C MbanefoDivision of Urology, Children's National Medical Center , Washington, District of Columbia.
Loc H LeBladder Immunology Group, Biomedical Research Institute , Rockville, Maryland.
Luke F PenningtonDepartment of Structural Biology, Stanford University School of Medicine , Stanford, California.
Justin I OdegaardGuardant Health, Redwood City, California.
Theodore S JardetzkyDepartment of Structural Biology, Stanford University School of Medicine , Stanford, California.
Abdulaziz AlouffiLife Science and Environment Sector, King Abdulaziz City for Science and Technology, Riyadh , Saudi Arabia.
Jude AkinwaleDivision of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham , Nottingham , United Kingdom.
Franco H FalconeDivision of Molecular Therapeutics and Formulation, School of Pharmacy, University of Nottingham , Nottingham , United Kingdom.
Michael H HsiehDivision of Urology, Children's National Medical Center , Washington, District of Columbia.
Biomedical Research Institute · USStanford University · USUniversity of Nottingham · GBGuardant (United States) · USKing Abdulaziz City for Science and Technology · SA

Funding

Therapeutic Exploitation of IPSE, a Urogenital Parasite-Derived Host Modulatory Protein, for Bladder Hypersensitivity SyndromesR01DK113504 · NIDDK · CHILDREN'S RESEARCH INSTITUTE · PI HSIEH, MICHAEL HARRISON · 2017 to 2021
$2.4M
NIDDK NIH HHS R01 DK113504
6 · The paper itself

Abstract

Chemotherapy-induced hemorrhagic cystitis is characterized by bladder pain and voiding dysfunction caused by hemorrhage and inflammation. Novel therapeutic options to treat hemorrhagic cystitis are needed. We previously reported that systemic administration of the

Indexed as

Administration, IntravesicalAnimalsBasophilsCell LineCell ProliferationCystitisDisease Models, AnimalEgg ProteinsFemaleHelminth ProteinsHemorrhageHumansIfosfamideImmunoglobulin EImmunologic FactorsInjections, IntravenousEgg ProteinsHelminth ProteinsIfosfamideIl4 protein, mouseImmunoglobulin EImmunologic FactorsInterleukin-4IPSE protein, Schistosoma mansoniNFATC Transcription Factorshemorrhagic cystitisIL-4IPSEschistosomiasis

Identifiers

PMID30785353
PMCPMC6620591
OpenAlexW2888072518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.