ArticleAnnals of neurology2019
Homocysteine and small vessel stroke: A mendelian randomization analysis.
Article in Annals of neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 2 of them syntheses that pooled it.
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Who cites it
53 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mendelian randomization studies on ischemic stroke: a field synopsis and systematic review.Journal of translational medicine · 2025Pooled it
- Homocysteine and female fertility, pregnancy loss and offspring birthweight: a two-sample Mendelian randomization study.European journal of clinical nutrition · 2022Pooled it
- The causal effects of hypothyroidism on cardiovascular disease: Bidirectional and multivariable Mendelian randomization study.Journal of diabetes investigation · 2026Article
- Research Progress on the Effect of Exercise on Homocysteine.Current medicinal chemistry · 2026Review
- Role and Relationship Between Homocysteine and HMolecular neurobiology · 2025Review
- The pathogenesis of cerebral small vessel disease and vascular cognitive impairment.Physiological reviews · 2025Review
- The causal role of homocysteine in multiple diseases: a systematic review of Mendelian randomization studies.Nutrition & metabolism · 2025Review
- Lipoprotein(a), high-sensitivity c-reactive protein, homocysteine and cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis.American journal of preventive cardiology · 2025Article
- Factors influencing the occurrence of ischemic stroke in elderly patients with hypertension and type 2 diabetes mellitus: a case-control study.BMC neurology · 2025Article
- Serum levels of vitamin B12 combined with folate and plasma total homocysteine predict ischemic stroke disease: a retrospective case-control study.Nutrition journal · 2024Article
- Associations of Circulating Biomarkers with Disease Risks: A Two-Sample Mendelian Randomization Study.International journal of molecular sciences · 2024Article
- Associations of Circulating Biomarkers with Disease Risks: a Two-Sample Mendelian Randomization Study.medRxiv : the preprint server for health sciences · 2024Article
- Stroke and frailty index: a two-sample Mendelian randomisation study.Aging clinical and experimental research · 2024Article
- Homocysteine levels in first-episode patients with psychiatric disorders.Frontiers in psychiatry · 2024Article
- The Multitarget Action of Vitamins in the Ischemic Stroke.Current topics in medicinal chemistry · 2024Review
- Associations of dietary, sociodemographic, and anthropometric factors with anemia among the Zhuang ethnic adults: a cross-sectional study in Guangxi Zhuang Autonomous Region, China.BMC public health · 2023Article
- Association Between Plasma Homocysteine Level and Mortality: A Mendelian Randomization Study.Korean circulation journal · 2023Article
- Lesion location and serum levels of homocysteine are associated with early-onset post-stroke depression in acute ischemic stroke.Brain and behavior · 2023Article
- Multi-ancestry meta-analysis identifies 5 novel loci for ischemic stroke and reveals heterogeneity of effects between sexes and ancestries.Cell genomics · 2023Article
- Methylenetetrahydrofolate reductase polymorphisms and elevated plasma homocysteine levels in small vessel disease.Brain and behavior · 2023Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
objectiveTrials of B vitamin therapy to lower blood total homocysteine (tHcy) levels for prevention of stroke are inconclusive. Secondary analyses of trial data and epidemiological studies suggest that tHcy levels may be particularly associated with small vessel stroke (SVS). We assessed whether circulating tHcy and B vitamin levels are selectively associated with SVS, but not other stroke subtypes, using Mendelian randomization.
methodsWe used summary statistics data for single-nucleotide polymorphisms (SNPs) associated with tHcy (n = 18), folate (n = 3), vitamin B
resultsGenetically predicted tHcy was associated with SVS, with an odds ratio of 1.34 (95% confidence interval [CI], 1.13-1.58; p = 6.7 × 10
interpretationThese findings suggest that any effect of homocysteine-lowering treatment in preventing stroke will be confined to the SVS subtype. Whether genetic variants at or near the MTHFR and MUT genes influence SVS risk through pathways other than homocysteine levels and downstream effects require further investigation. Ann Neurol 2019;85:495-501.
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