ArticleLab on a chip2019
Lipid coated liquid crystal droplets for the on-chip detection of antimicrobial peptides.
Article in Lab on a chip, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Microfluidics-Assisted Three-Dimensional Confinement of Cholesteric Liquid Crystals for Sensing Applications.Micromachines · 2026Review
- Fluorescence Transduction of Liquid Crystal Ordering Transitions for Biosensing.Journal of the American Chemical Society · 2026Article
- Liquid crystal-aqueous interface renders selective detection of distinct mycobacterial cell envelope responses.Journal of materials chemistry. B · 2025Article
- Slippery Liquid-Infused Porous Surfaces Infused with Thermotropic Liquid Crystals Enable Droplet-Based, Naked-Eye Reporting of Changes in Peptide Structure and Protease Activity.ACS applied materials & interfaces · 2025Article
- Article
- Membrane Proteins in Action Monitored by pH-Responsive Liquid Crystal Biosensors.ACS applied materials & interfaces · 2024Article
- Molecular Orientation Behavior of Lyotropic Liquid Crystal-Carbon Dot Hybrids in Microfluidic Confinement.International journal of molecular sciences · 2024Article
- Recent Progress in Droplet Structure Machining for Advanced Optics.Micromachines · 2024Review
- The good, the bad and the ugly faces of cyanobiphenyl mesogens in selected tracks of fundamental and applied liquid crystal research.Liquid crystals · 2024Article
- Tuning Molecular Orientation Responses of Microfluidic Liquid Crystal Dispersions to Colloid and Polymer Flows.International journal of molecular sciences · 2023Article
- Ultra-stable liquid crystal droplets coated by sustainable plant-based materials for optical sensing of chemical and biological analytes.Journal of materials chemistry. C · 2023Article
- Heads or tails: investigating the effects of amphiphile features on the distortion of chiral nematic liquid crystal droplets.Journal of materials chemistry. C · 2023Article
- Venom biotechnology: casting light on nature's deadliest weapons using synthetic biology.Frontiers in bioengineering and biotechnology · 2023Review
- Review
- Designing Biological Microsensors with Chiral Nematic Liquid Crystal Droplets.ACS applied materials & interfaces · 2022Article
- Liquid Crystal Biosensors: Principles, Structure and Applications.Biosensors · 2022Review
- Chiral nematic liquid crystal droplets as a basis for sensor systems.Molecular systems design & engineering · 2022Article
- Article
- Therapeutic Effects of Synthetic Triblock Amphiphilic Short Antimicrobial Peptides on Human Lung Adenocarcinoma.Pharmaceutics · 2022Article
- Applications of Microfluidics in Liquid Crystal-Based Biosensors.Biosensors · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
We describe a novel biosensor based on phospholipid-coated nematic liquid crystal (LC) droplets and demonstrate the detection of Smp43, a model antimicrobial peptide (AMP) from the venom of North African scorpion Scorpio maurus palmatus. Mono-disperse lipid-coated LC droplets of diameter 16.7 ± 0.2 μm were generated using PDMS microfluidic devices with a flow-focusing configuration and were the target for AMPs. The droplets were trapped in a bespoke microfluidic trap structure and were simultaneously treated with Smp43 at gradient concentrations in six different chambers. The disruption of the lipid monolayer by the Smp43 was detected (<6 μM) at concentrations well within its biologically active range, indicated by a dramatic change in the appearance of the droplets associated with the transition from a typical radial configuration to a bipolar configuration, which is readily observed by polarizing microscopy. This suggests the system has feasibility as a drug-discovery screening tool. Further, compared to previously reported LC droplet biosensors, this LC droplet biosensor with a lipid coating is more biologically relevant and its ease of use in detecting membrane-related biological processes and interactions has the potential for development as a reliable, low-cost and disposable point of care diagnostic tool.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.