ArticlePsychiatry research. Neuroimaging2019
Preliminary results from a pilot study examining brain structure in older adult cannabis users and nonusers.
Article in Psychiatry research. Neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Behavioral Sequelae of Cannabis Use in Healthy People: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Lifetime Cannabis Use Is Associated With Brain Volume and Cognitive Function in Middle-Aged and Older Adults.Journal of studies on alcohol and drugs · 2026Article
- Age-Related Effects of Cannabis and Cannabinoids on Brain and Behavior.Cannabis and cannabinoid research · 2026Review
- History of cannabis use and cognitive function in older adults: findings from the UK biobank.Age and ageing · 2025Article
- The impact of cannabis use on ageing and longevity: a systematic review of research insights.Journal of cannabis research · 2025Review
- Effects of cannabis smoke and oral Δ9THC on cognition in young adult and aged rats.Psychopharmacology · 2025Article
- Axis I Psychiatric Disorders and Substance Abuse: A Systematic Review of Neuroimaging Findings.Journal of clinical medicine · 2025Review
- Residual and enduring effects of cannabis use on cognitive and psychomotor function: A study of adults during unrestricted cannabis use, short-term abstinence, and protracted abstinence.Experimental and clinical psychopharmacology · 2025Article
- Marijuana use among community-dwelling older adults: A population-based study.International journal of geriatric psychiatry · 2024Article
- Potential Risks from Cannabis-Infused Beverages: A Critical Review.Cannabis (Albuquerque, N.M.) · 2024Article
- A longitudinal study of cannabis use and risk for cognitive and functional decline among older adults with HIV.AIDS and behavior · 2023Article
- Effects of inhaled cannabis high in Δ9-THC or CBD on the aging brain: A translational MRI and behavioral study.Frontiers in aging neuroscience · 2023Article
- Impacts of medical and non-medical cannabis on the health of older adults: Findings from a scoping review of the literature.PloS one · 2023Article
- Differences in Inhibitory Control and Resting Brain Metabolism between Older Chronic Users of Tetrahydrocannabinol (THC) or Cannabidiol (CBD)-A Pilot Study.Brain sciences · 2022Article
- Long-Term Cannabis Use and Cognitive Reserves and Hippocampal Volume in Midlife.The American journal of psychiatry · 2022Article
- Cannabis Use and Resting State Functional Connectivity in the Aging Brain.Frontiers in aging neuroscience · 2022Article
- The Neurocognitive Effects of Cannabis Across the Lifespan.Current behavioral neuroscience reports · 2021Article
- The Effects of Cannabis Use on Cognitive Function in Healthy Aging: A Systematic Scoping Review.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2021Article
- Increased Likelihood of Falling in Older Cannabis Users vs. Non-Users.Brain sciences · 2021Article
- Investigating Associations Between Inflammatory Biomarkers, Gray Matter, Neurofilament Light and Cognitive Performance in Healthy Older Adults.Frontiers in aging neuroscience · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Exploring associations among cannabis use, brain structure, and cognitive function in older adults offers an opportunity to observe potential harm or benefit of cannabis. This pilot study assessed structural magnetic resonance imaging in older adults who were either current cannabis users (n = 28; mean age 69.8 years, 36% female) or nonusers (n = 28; mean age 66.8 years, 61% female). Recruitment targeted users who reported at least weekly use for at least the last year, although users had 23.55 years of regular cannabis use on average (SD=19.89, range 1.5-50 years). Groups were not significantly different in terms of sex, years of education, alcohol use, or anxiety symptoms, but were significantly different in age and depression symptoms. Users and nonusers did not differ in terms of total gray or white matter volumes controlling for age and depression symptoms, but users showed greater regional volume of left putamen, lingual cortex, and rostral middle frontal cortex. No significant differences between groups were observed in performance on a brief computerized cognitive battery. These results suggest that cannabis use likely does not have a widespread impact on overall cortical volume while controlling for age.
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