Evidence map›Paper›PMID 30784923›Full record

ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2019

Effects of plasma glucose levels on regional cerebral 18F-fluorodeoxyglucose uptake: Implications for dementia evaluation with brain PET imaging.

Benjamin L Viglianti, Daniel J Wale, Tianwen Ma, Timothy D Johnson, Nicolaas I Bohnen, Ka Kit Wong, Christy Ky, Kirk A Frey, Danyelle M Townsend, Domenico Rubello and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. EANM procedure guidelines for brain PET imaging using [European journal of nuclear medicine and molecular imaging · 2022
    Article
  5. Article
  6. Article
  7. Effect of various blood glucose levels on regional FDG uptake in the brain.Asia Oceania journal of nuclear medicine & biology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Benjamin L VigliantiDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Nuclear Medicine Service, Department of Veterans Affairs Healthcare System, Ann Arbor, MI, USA. Electronic address: bviglia@med.umich.edu.
Daniel J WaleDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Nuclear Medicine Service, Department of Veterans Affairs Healthcare System, Ann Arbor, MI, USA.
Tianwen MaDepartment of Biostatistics, University of Michigan, School of Public Health, Ann Arbor, MI, USA.
Timothy D JohnsonDepartment of Biostatistics, University of Michigan, School of Public Health, Ann Arbor, MI, USA.
Nicolaas I BohnenDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Nuclear Medicine Service, Department of Veterans Affairs Healthcare System, Ann Arbor, MI, USA.
Ka Kit WongDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Christy KyUniversity of Michigan School of Medicine, University of Michigan, Ann Arbor, MI, USA.
Kirk A FreyDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, USA.
Danyelle M TownsendDepartment of Physiology, Division of New Drugs Development, University of Southern Carolina, USA.
Domenico RubelloDepartment of Nuclear Medicine, Santa Maria della Misericordia Hospital, Rovigo, Italy. Electronic address: domenico.rubello@libero.it.
Milton D GrossDivision of Nuclear Medicine, Department of Radiology, University of Michigan, Ann Arbor, MI, USA; Nuclear Medicine Service, Department of Veterans Affairs Healthcare System, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USVA Ann Arbor Healthcare System · USOspedale Santa Maria della Misericordia di Rovigo · IT

Funding

SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20GM103542 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2012 to 2020
$20.2M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DINOV, IVO D · 2014 to 2019
$10.1M
SOUTH CAROLINA COBRE IN OXIDANTS, REDOX BALANCE AND STRESS SIGNALINGP20RR024485 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI TEW, KENNETH D. · 2011 to 2011
$2.2M
NCRR NIH HHS P20 RR024485NIGMS NIH HHS P20 GM103542NINDS NIH HHS P50 NS091856
6 · The paper itself

Abstract

purposeHyperglycemia affects FDG uptake in the brain, potentially emulating Alzheimer's disease in normal individuals. This study investigates global and regional cerebral FDG uptake as a function of plasma glucose in a cohort of patients.

methods120 consecutive male patients with FDG PET/CT for initial oncologic staging (July-Dec 2015) were reviewed. Patients with dementia, cerebrovascular accident, structural brain lesion, prior oncology treatment or high metabolic tumor burden (recently shown affecting brain FDG uptake) were excluded. 53 (24 nondiabetic) eligible patients (age 65.7 ± 2.8 mean ± SE) were analyzed with parametric computer software, MIMneuro™. Regional Z-scores were evaluated as a function of plasma glucose and age using multi variable linear mixed effects models with false discovery analysis adjusting for multiple comparisons. If the regression slope was significantly (p < 0.05) different than zero, hyperglycemia effect was present.

resultsThere was a negative inverse relationship (p < 0.001) between global brain FDG uptake and hyperglycemia. No regional hyperglycemia effect on uptake were present when subjects were normalized using pons or cerebellum. However, regional hyperglycemia effects were seen (p < 0.047-0.001) when normalizing by the whole brain. No obvious pattern was seen in the regions affected. Age had a significant effect using whole brain normalization (p < 0.04-0.01).

conclusionsCortical variation in FDG uptake were identified when subjects were hyperglycemic. However, these variations didn't fit a particular pattern of dementia and the severity of the affect is not likely to alter clinical interpretation.

Indexed as

Positron Emission Tomography Computed TomographyAgedBlood GlucoseBrainFluorodeoxyglucose F18HumansHyperglycemiaMaleRadiopharmaceuticalsRetrospective StudiesBlood GlucoseFluorodeoxyglucose F18RadiopharmaceuticalsFDG uptake in hyperglycemiaMisdiagnosis of dementiaNondiabetic patientsRegional cerebral FDG uptake

Identifiers

PMID30784923
PMCPMC6714976
OpenAlexW2915570295

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.