Evidence map›Paper›PMID 30784684›Full record

SynthesisJACC. Clinical electrophysiology2019

Wearable Cardioverter-Defibrillator Therapy for the Prevention of Sudden Cardiac Death: A Systematic Review and Meta-Analysis.

Ahmad Masri, Ahmed M Altibi, Sebhat Erqou, Mohammad A Zmaili, Ala Saleh, Raed Al-Adham, Karam Ayoub, Moaaz Baghal, Laith Alkukhun, Amr F Barakat and 3 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in JACC. Clinical electrophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. A review on wearable cardioverter-defibrillators in clinical practice for sudden cardiac death prevention and heart failure management.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Review
  7. Role of the wearable cardioverter defibrillator in the initial period of sudden cardiac death risk stratification: results of a European Heart Rhythm Association survey.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. International journal of cardiology. Heart & vasculature · 2023
    Article
  15. International journal of cardiology. Heart & vasculature · 2023
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Sudden cardiac death while waiting: do we need the wearable cardioverter-defibrillator?Clinical research in cardiology : official journal of the German Cardiac Society · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Ahmad MasriHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania. Electronic address: masria@upmc.edu.
Ahmed M AltibiHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Sebhat ErqouDepartment of Medicine, Providence VA Medical Center and Alpert Medical School of Brown University, Providence, Rhode Island.
Mohammad A ZmailiHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Ala SalehHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Raed Al-AdhamDepartment of Medicine, University of Arizona, Phoenix, Arizona.
Karam AyoubDivision of Cardiology, Department of Medicine, University of Kentucky, Lexington, Kentucky.
Moaaz BaghalHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Laith AlkukhunHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Amr F BarakatHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Sandeep JainHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Samir SabaHeart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
Evan AdelsteinDivision of Cardiology, Albany Medical College, Albany, New York.
University of Pittsburgh Medical Center · USAlbany Medical Center Hospital · USBrown University · USUniversity of Arizona · USUniversity of Kentucky · US

Funding

Training Program in Imaging Sciences in Translational Cardiovascular ResearchT32HL129964 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Flordeliza S Villanueva · 2016 to 2026
$4.7M
NHLBI NIH HHS T32 HL129964
6 · The paper itself

Abstract

objectivesThis study sought to synthesize the available evidence on the use of the wearable cardioverter-defibrillator (WCD).

backgroundObservational WCD studies for the prevention of sudden cardiac death have provided conflicting data. The VEST (Vest Prevention of Early Sudden Death) trial was the first randomized controlled trial (RCT) showing no reduction in sudden cardiac death as compared to medical therapy only.

methodsWe searched PubMed, EMBASE, and Google Scholar for studies reporting on the outcomes of patients wearing WCDs from January 1, 2001, through March 20, 2018. Rates of appropriate and inappropriate WCD therapies were pooled. Estimates were derived using DerSimonian and Laird's method.

resultsTwenty-eight studies were included (N = 33,242; 27 observational, 1 RCT-WCD arm). The incidence of appropriate WCD therapy was 5 per 100 persons over 3 months (95% confidence interval [CI]: 3.0 to 6.0, I

conclusionsThe rate of appropriately treated WCD patients over 3 months of follow-up was substantial; higher in-observational studies as compared with the VEST trial. There was significant heterogeneity. More RCTs are needed to justify continued use of WCD in primary prevention.

Indexed as

Death, Sudden, CardiacDefibrillators, ImplantableElectric CountershockAdultAgedFemaleHumansIncidenceMaleMiddle Ageddeathmeta-analysisshocksystematic reviewwearable cardioverter-defibrillator

Identifiers

PMID30784684
PMCPMC6383782
OpenAlexW2914234753

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.