Evidence map›Paper›PMID 30784602›Full record

ArticleCell reports2019

Whole-Organ Genomic Characterization of Mucosal Field Effects Initiating Bladder Carcinogenesis.

Tadeusz Majewski, Hui Yao, Jolanta Bondaruk, Woonbok Chung, Sangkyou Lee, June Goo Lee, Shizhen Zhang, David Cogdell, Guoliang Yang, Woonyoung Choi and 12 more

Open access · goldAbstract read
PubMed Publisher
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 48 citations in OpenAlex.

  1. Review
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  7. Observational
  8. Imposter among us: field cancerization in the bladder.Translational andrology and urology · 2024
    Article
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  10. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 1 country.

Tadeusz MajewskiDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Hui YaoDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jolanta BondarukDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Woonbok ChungFels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA, USA.
Sangkyou LeeDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
June Goo LeeDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Shizhen ZhangDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
David CogdellDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Guoliang YangDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Woonyoung ChoiJohns Hopkins Greenberg Bladder Cancer Institute, Johns Hopkins University, Baltimore, MD, USA.
Colin DinneyDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
H Barton GrossmanDepartment of Urology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Christopher LogothetisDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Steven E SchererHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA.
Charles C GuoDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Li ZhangDepartment of Environmental Health, University of Cincinnati, Cincinnati, OH, USA.
Peng WeiDepartment of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
John N WeinsteinDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Jean-Pierre IssaFels Institute for Cancer Research and Molecular Biology, Temple University, Philadelphia, PA, USA.
Keith BaggerlyDepartment of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: kabagger@mdanderson.org.
David J McConkeyJohns Hopkins Greenberg Bladder Cancer Institute, Johns Hopkins University, Baltimore, MD, USA. Electronic address: dmcconk1@jhmi.edu.
Bogdan CzerniakDepartment of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address: bczernia@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USJohns Hopkins University · USTemple University · USBaylor College of Medicine · USUniversity of Cincinnati · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We used whole-organ mapping to study the locoregional molecular changes in a human bladder containing multifocal cancer. Widespread DNA methylation changes were identified in the entire mucosa, representing the initial field effect. The field effect was associated with subclonal low-allele frequency mutations and a small number of DNA copy alterations. A founder mutation in the RNA splicing gene, ACIN1, was identified in normal mucosa and expanded clonally with an additional 21 mutations in progression to carcinoma. The patterns of mutations and copy number changes in carcinoma in situ and foci of carcinoma were almost identical, confirming their clonal origins. The pathways affected by the DNA copy alterations and mutations, including the Kras pathway, were preceded by the field changes in DNA methylation, suggesting that they reinforced mechanisms that had already been initiated by methylation. The results demonstrate that DNA methylation can serve as the initiator of bladder carcinogenesis.

Indexed as

Clonal EvolutionDNA MethylationCarcinogenesisCarcinomaGenome, HumanHumansMaleMiddle AgedMucous MembraneMutationNuclear ProteinsUrinary Bladder NeoplasmsUrotheliumACIN1 protein, humanNuclear Proteinsbladder cancerclonal expansionclonal originsDNA copy alterationsDNA methylationfield effectfounder mutationgene signatureurothelial carcinomaWhole-organ map

Identifiers

PMID30784602
OpenAlexW2916147515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.