ArticleCell reports2019
Decoupling the Roles of Cell Shape and Mechanical Stress in Orienting and Cueing Epithelial Mitosis.
Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Modeling epithelial deformation and cell rearrangement in response to external forces during Zebrafish epiboly.NPJ systems biology and applications · 2026Article
- Direct Observation and Measurement of Membrane Tension in Xenopus laevis Animal Cap Explants Using the Mechanosensitive Dye, Flipper-TR.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Biomechanical Studies with Xenopus Animal Caps: A 3D-Printed Mechanical Bracket for Maintaining Tissue Stretch During Immunofluorescence Analysis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025Article
- Review
- Nonmuscle myosin IIA (NMIIA) regulates anisotropic cell tension to maintain the hexagonal packing of mouse lens meridional row cells.Molecular biology of the cell · 2025Article
- Neighbor cells restrain furrowing during Xenopus epithelial cytokinesis.Developmental cell · 2025Article
- The TissueTractor: A Device for Applying Large Strains to Tissues and Cells for Simultaneous High-Resolution Live Cell Microscopy.Small methods · 2025Article
- Apical size reduction by macropinocytosis alleviates tissue crowding.Nature communications · 2025Article
- Spindle Orientation Regulation Is Governed by Redundant Cortical Mechanosensing and Shape-Sensing Mechanisms.International journal of molecular sciences · 2025Article
- Article
- An eGFP-Col4a2 mouse model reveals basement membrane dynamics underlying hair follicle morphogenesis.The Journal of cell biology · 2025Article
- Fast yet force-effective mode of supracellular collective cell migration due to extracellular force transmission.PLoS computational biology · 2025Article
- Capturing the mechanosensitivity of cell proliferation in models of epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Compressive stresses in cancer: characterization and implications for tumour progression and treatment.Nature reviews. Cancer · 2024Review
- Deep learning for rapid analysis of cell divisions in vivo during epithelial morphogenesis and repair.eLife · 2024Article
- Spectral approaches to stress relaxation in epithelial monolayers.Proceedings. Mathematical, physical, and engineering sciences · 2024Article
- Advances in micropatterning technology for mechanotransduction research.Mechanobiology in medicine · 2024Review
- Relaxation and Noise-Driven Oscillations in a Model of Mitotic Spindle Dynamics.Bulletin of mathematical biology · 2024Article
- The TissueTractor, a device for applying large strains to tissues and cells for simultaneous high-resolution live cell microscopy.bioRxiv : the preprint server for biology · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Distinct mechanisms involving cell shape and mechanical force are known to influence the rate and orientation of division in cultured cells. However, uncoupling the impact of shape and force in tissues remains challenging. Combining stretching of Xenopus tissue with mathematical methods of inferring relative mechanical stress, we find separate roles for cell shape and mechanical stress in orienting and cueing division. We demonstrate that division orientation is best predicted by an axis of cell shape defined by the position of tricellular junctions (TCJs), which align with local cell stress rather than tissue-level stress. The alignment of division to cell shape requires functional cadherin and the localization of the spindle orientation protein, LGN, to TCJs but is not sensitive to relative cell stress magnitude. In contrast, proliferation rate is more directly regulated by mechanical stress, being correlated with relative isotropic stress and decoupled from cell shape when myosin II is depleted.
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